菲律宾采集的海绵 Haliclona sp. 中分离得到的卤代环酸 A 和 B 抑制吲哚胺 2,3-双加氧酶。

Halicloic acids A and B isolated from the marine sponge Haliclona sp. collected in the Philippines inhibit indoleamine 2,3-dioxygenase.

机构信息

Department of Chemistry, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.

出版信息

J Nat Prod. 2012 Aug 24;75(8):1451-8. doi: 10.1021/np300345j. Epub 2012 Aug 7.

Abstract

Two new merohexaprenoids, halicloic acids A (1) and B (2), have been isolated from the marine sponge Haliclona (Halichoclona) sp. collected in the Philippines. The glycolic acids 1 and 2 slowly decomposed during acquisition of NMR data to aldehydes 3 and 4, respectively, via an oxidative decarboxylation. Halicloic acid B (2) has the new rearranged "haliclane" meroterpenoid carbon skeleton. The halicloic acids 1 and 2 are indoleamine 2,3-dioxygenase inhibitors that are significantly more active than the decomposition products 3 and 4.

摘要

两种新的单萜类化合物，halicloic 酸 A（1）和 B（2），已从菲律宾采集的海洋海绵 Haliclona（Halichoclona）sp 中分离出来。在获取 NMR 数据的过程中，2-羟基乙酸 1 和 2 分别缓慢分解为相应的醛 3 和 4，这是通过氧化脱羧作用实现的。Halicloic 酸 B（2）具有新的重排的“haliclane”单萜类化合物碳骨架。halicloic 酸 1 和 2 是吲哚胺 2,3-双加氧酶抑制剂，其活性明显高于分解产物 3 和 4。