The NeaNat Group, Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
Mar Drugs. 2013 May 17;11(5):1602-43. doi: 10.3390/md11051602.
Meroterpenes are widely distributed among marine organisms; they are particularly abundant within brown algae, but other important sources include microorganisms and invertebrates. In the present review the structures and bioactivities of meroterpenes from marine invertebrates, mainly sponges and tunicates, are summarized. More than 300 molecules, often complex and with unique skeletons originating from intra- and inter-molecular cyclizations, and/or rearrangements, are illustrated. The reported syntheses are mentioned. The issue of a potential microbial link to their biosynthesis is also shortly outlined.
海洋生物中广泛分布着生源二萜类化合物；它们在褐藻中含量特别丰富，但其他重要的生源来源还包括微生物和无脊椎动物。在本综述中，总结了海洋无脊椎动物（主要是海绵和被囊动物）生源二萜类化合物的结构和生物活性。文中展示了 300 多种分子，它们通常结构复杂，具有独特的骨架，源于分子内和分子间的环化和/或重排。文中还提到了部分化合物的合成方法。此外，还简要概述了它们生物合成的潜在微生物联系问题。
