Department of Oceanography, Kunsan National University, Jeonbuk 573-701, South Korea.
Org Lett. 2012 Dec 21;14(24):6154-7. doi: 10.1021/ol3028303. Epub 2012 Dec 5.
Densanins A (1) and B (2) were isolated from the sponge Haliclona densaspicula. On the basis of spectral data and the Mosher ester method, the complete structures were characterized as hexacyclic diamine alkaloids, which were probably derived from 3-alkylpyridine. Compounds 1 and 2 showed relatively potent inhibitory effects on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells with IC(50) values of 1.05 and 2.14 μM, respectively.
丹萨宁 A（1）和 B（2）从海绵 Haliclona densaspicula 中分离得到。基于光谱数据和 Mosher 酯法，确定了它们的完整结构为六环二胺生物碱，可能来源于 3-烷基吡啶。化合物 1 和 2 对 LPS 诱导的 BV2 小胶质细胞中一氧化氮的产生具有较强的抑制作用，IC50 值分别为 1.05 和 2.14 μM。
