Neville Brian
UCL Institute of Child Health, Neurosciences Unit, London, United Kingdom.
Brain Dev. 2013 Feb;35(2):128-32. doi: 10.1016/j.braindev.2012.06.011. Epub 2012 Aug 6.
Early Symptomatic Syndromes Eliciting Neurodevelopmental Examinations (ESSENCE) has been proposed as a guide to the neurodevelopmental needs of the under 5s. The problems are their multiplicity, the presence of partial features of specific conditions e.g. autism spectrum disorder and attention deficit/hyperactivity disorder and the young age of the children. For these reasons, child development teams often leave families to cope with very difficult situations. This paper includes epilepsy and the cerebral palsies to see if providing precise diagnostic categories and therapeutic targets can be achieved. It includes a discussion of causal sequences which have yet to be applied comprehensively to the neurodevelopment disorders.
早期症状引发神经发育检查综合征（ESSENCE）已被提议作为指导5岁以下儿童神经发育需求的指南。问题在于其多样性、特定病症（如自闭症谱系障碍和注意力缺陷多动障碍）部分特征的存在以及儿童年龄较小。由于这些原因，儿童发育团队常常让家庭去应对非常困难的情况。本文纳入了癫痫和脑瘫，以探讨是否能够实现提供精确的诊断类别和治疗靶点。文中还讨论了尚未全面应用于神经发育障碍的因果序列。
