Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University Clayton Campus, Victoria, Australia.
Autophagy. 2012 Nov;8(11):1701-5. doi: 10.4161/auto.21332. Epub 2012 Aug 9.
In autophagic processes a variety of cargos is delivered to the degradative compartment of cells. Recent progress in autophagy research has provided support for the notion that when autophagic processes are operating in selective mode, a receptor protein complex will process the cargo. Here we present a concept of receptor protein complexes as comprising a functional tetrad of components: a ligand, a receptor, a scaffold and an Atg8 family protein. Our current understanding of each of the four components and their interaction in the context of cargo selection are considered in turn.
在自噬过程中,各种货物被递送到细胞的降解隔室。自噬研究的最新进展为这样一种观点提供了支持,即当自噬过程以选择性模式运行时,一个受体蛋白复合物将处理货物。在这里,我们提出了一个受体蛋白复合物的概念,它由一个功能四联体组成:配体、受体、支架和 Atg8 家族蛋白。我们依次考虑了对四个组件中的每一个及其在货物选择背景下的相互作用的当前理解。