Faculty of Medicine, Department of Pediatrics, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Am J Perinatol. 2013 Mar;30(3):215-8. doi: 10.1055/s-0032-1323582. Epub 2012 Aug 8.
Fetal calprotectin levels increase in the early stages of necrotizing enterocolitis. Although the effects of several factors on fetal calprotectin have been studied, the effect of phototherapy is not known. In this study, we analyzed the effect of phototherapy on fetal calprotectin levels.
Ninety breast-fed newborns (46 male, 44 female) who were hospitalized for indirect hyperbilirubinemia and treated with phototherapy were included to the study. Forty-two of them were term and 44 of them were preterm. Newborns treated with phototherapy (n = 53) constituted the phototherapy group (29 preterm, 24 term) and 37 newborns who did not receive phototherapy (19 preterm, 18 term) constituted the control group. Fecal samples were collected 24 hours after phototherapy had been started. Fecal samples (100 mg) were weighed with sensitive scales and preserved at -80°C after buffering with a special solution. All samples were studied at the same time with a fecal calprotectin kit by using enzyme-linked immunosorbent assay.
There were no statistically significant difference between fecal calprotectin levels of term and preterm babies who received phototherapy and babies who did not receive phototherapy.
There was no effect of 24-hour phototherapy on fecal calprotectin levels in preterm and term newborns.
坏死性小肠结肠炎（NEC）早期阶段胎儿钙卫蛋白水平升高。尽管已经研究了多种因素对胎儿钙卫蛋白的影响，但光疗的影响尚不清楚。本研究分析了光疗对胎儿钙卫蛋白水平的影响。
本研究纳入了 90 名因间接高胆红素血症住院并接受光疗的母乳喂养新生儿（男 46 例，女 44 例）。其中 42 例为足月儿，44 例为早产儿。接受光疗的新生儿（n=53）为光疗组（29 例早产儿，24 例足月儿），37 名未接受光疗的新生儿（19 例早产儿，18 例足月儿）为对照组。光疗开始后 24 小时采集粪便样本。用灵敏天平称取 100mg 粪便样本，用特殊溶液缓冲后保存在-80°C。所有样本均同时用粪便钙卫蛋白试剂盒通过酶联免疫吸附试验进行研究。
接受光疗和未接受光疗的早产儿和足月儿的粪便钙卫蛋白水平无统计学差异。
24 小时光疗对早产儿和足月儿的粪便钙卫蛋白水平没有影响。
