Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2012 Aug;27(8):922-8. doi: 10.3346/jkms.2012.27.8.922. Epub 2012 Jul 25.
Little is known about the prevalence and seroprevalence of low-risk human papillomavirus (HPV) and the risk factors for HPV infection in Korean women. We determined the prevalence of low-risk HPV among 902 women aged 20-59 yr and the seroprevalence of low-risk HPV subtypes 6 and 11 among 1,094 women aged 9-59 yr in the general population. Genital low-risk HPV DNA was assessed by liquid hybridization and polymerase chain reaction. Antibody titers against HPV 6 and 11 were measured by a multiplexed competitive luminex technique. The prevalence of genital low-risk HPV was 4.9%. It reached its highest peak of 10.3% at 20-29 yr of age and a second peak of 3.2% at 50-59 yr of age. The seroprevalence of HPV 6 or 11 was 9.4%. It reached its highest peak of 12.7% at 25-29 yr of age and a second peak of 12.3% at 50-59 yr of age. In multivariable analysis, the number of lifetime sexual partners and past history of sexually transmitted diseases were associated with the seroprevalence but not prevalence of HPV. It is suggested that younger women should receive prophylactic HPV vaccination before they become sexually active and exposed to HPV in their 20s. This study provides baseline data for developing HPV vaccination programs and monitoring vaccine efficacy in Korea.
关于韩国女性中低危型人乳头瘤病毒（HPV）的流行率和血清流行率以及 HPV 感染的危险因素，人们知之甚少。我们确定了 902 名 20-59 岁女性中低危型 HPV 的流行率，以及 1094 名 9-59 岁女性中低危型 HPV 亚型 6 和 11 的血清流行率。通过液体杂交和聚合酶链反应评估生殖道低危型 HPV DNA。通过多重竞争 Luminex 技术测量针对 HPV 6 和 11 的抗体滴度。生殖道低危型 HPV 的流行率为 4.9%。它在 20-29 岁年龄组达到最高峰值 10.3%，在 50-59 岁年龄组达到第二个峰值 3.2%。HPV 6 或 11 的血清流行率为 9.4%。它在 25-29 岁年龄组达到最高峰值 12.7%，在 50-59 岁年龄组达到第二个峰值 12.3%。在多变量分析中，性伴侣人数和性传播疾病史与 HPV 血清流行率有关，但与 HPV 流行率无关。建议年轻女性在 20 多岁开始性行为并接触 HPV 之前接受预防性 HPV 疫苗接种。本研究为在韩国制定 HPV 疫苗接种计划和监测疫苗效果提供了基线数据。
