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Phase II trial of sorafenib combined with concurrent transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma.索拉非尼联合载药微球肝动脉化疗栓塞治疗肝细胞癌的 II 期临床试验。
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2
Transarterial chemoembolization with Doxorubicin-eluting microspheres for inoperable hepatocellular carcinoma.使用载阿霉素微球经动脉化疗栓塞治疗不可切除的肝细胞癌。
Gastrointest Cancer Res. 2011 Jan;4(1):2-8.
3
Hepatic resection versus transarterial lipiodol chemoembolization as the initial treatment for large, multiple, and resectable hepatocellular carcinomas: a prospective nonrandomized analysis.肝切除术与经动脉碘油化疗栓塞作为大、多发且可切除肝癌的初始治疗:一项前瞻性非随机分析。
Radiology. 2011 Apr;259(1):286-95. doi: 10.1148/radiol.10101072. Epub 2011 Feb 17.
4
Novel intraarterial therapy for liver cancer using ethylbromopyruvate dissolved in an iodized oil.新型肝癌动脉内治疗药物:碘油包裹的乙基溴丙酮酸。
Acad Radiol. 2011 Apr;18(4):471-8. doi: 10.1016/j.acra.2010.12.001. Epub 2011 Jan 14.
5
Radioembolization results in longer time-to-progression and reduced toxicity compared with chemoembolization in patients with hepatocellular carcinoma.与化疗栓塞相比,放射性栓塞可使肝癌患者的疾病进展时间延长且毒性降低。
Gastroenterology. 2011 Feb;140(2):497-507.e2. doi: 10.1053/j.gastro.2010.10.049. Epub 2010 Oct 30.
6
Nonoperative therapies for combined modality treatment of hepatocellular cancer: expert consensus statement.肝癌联合治疗的非手术治疗方法:专家共识声明。
HPB (Oxford). 2010 Jun;12(5):313-20. doi: 10.1111/j.1477-2574.2010.00183.x.
7
Surgical treatment of hepatocellular carcinoma: expert consensus statement.肝细胞癌的外科治疗:专家共识声明。
HPB (Oxford). 2010 Jun;12(5):302-10. doi: 10.1111/j.1477-2574.2010.00182.x.
8
Hepatocellular carcinoma: CT for tumor response after transarterial chemoembolization in patients exceeding Milan criteria--selection parameter for liver transplantation.肝细胞癌:米兰标准外患者经肝动脉化疗栓塞后肿瘤反应的 CT 评价--肝移植的选择参数。
Radiology. 2010 Apr;255(1):289-300. doi: 10.1148/radiol.09090927.
9
Comparison of conventional transarterial chemoembolization (TACE) and chemoembolization with doxorubicin drug eluting beads (DEB) for unresectable hepatocelluar carcinoma (HCC).比较不可切除肝细胞癌(HCC)的传统经动脉化疗栓塞(TACE)与多柔比星载药微球(DEB)化疗栓塞。
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10
Therapeutic equivalence in survival for hepatic arterial chemoembolization and yttrium 90 microsphere treatments in unresectable hepatocellular carcinoma: a two-cohort study.不可切除肝细胞癌的肝动脉化疗栓塞和钇 90 微球治疗的生存治疗等效性:一项两队列研究。
Cancer. 2010 Mar 1;116(5):1305-14. doi: 10.1002/cncr.24884.

肝细胞癌经动脉治疗的新进展有哪些?

What's New in Transarterial Therapies for Hepatocellular Carcinoma?

作者信息

May Benjamin J, Murthy Ravi, Madoff David C

出版信息

Gastrointest Cancer Res. 2012 May;5(3 Suppl 1):S14-9.

PMID:22876334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3413029/
Abstract

Transarterial therapies play an important role in the treatment of hepatocellular carcinoma, both in a palliative setting and as an adjunct to surgery. These therapies exploit the dual blood supply of the liver to selectively target tumors via the hepatic artery, while sparing nontumorous liver. Currently available therapies include transarterial embolization; chemoembolization, with or without drug-eluting beads; and radioembolization. Transarterial techniques are also being used in the development of novel therapies. This article provides an outline of the technical and clinical applications of intraarterial therapies in the treatment of HCC and highlights pertinent future directions.

摘要

经动脉治疗在肝细胞癌的治疗中发挥着重要作用,无论是在姑息治疗还是作为手术辅助治疗方面。这些治疗方法利用肝脏的双重血液供应,通过肝动脉选择性地靶向肿瘤,同时保护非肿瘤性肝脏。目前可用的治疗方法包括经动脉栓塞术;化疗栓塞术,使用或不使用载药微球;以及放射性栓塞术。经动脉技术也正被用于新型治疗方法的研发。本文概述了动脉内治疗在肝癌治疗中的技术和临床应用,并突出了相关的未来发展方向。