Bouhuys A L, Flentge F, Van den Hoofdakker R H
Department of Biological Psychiatry, Academic Hospital, University of Groningen, The Netherlands.
Psychiatry Res. 1990 Nov;34(2):149-62. doi: 10.1016/0165-1781(90)90016-x.
The possibility that the clinical response to total sleep deprivation (TSD) is mediated by dimensions of arousal was investigated in a group of 16 depressed patients. Self-reports of activation, stress, and mood were assessed 3 days before, during, and 2 days after TSD. Urinary cortisol excretion and responses to the dexamethasone suppression test (DST) were also measured. TSD increased cortisol excretion in depressed patients and advanced the time of the maximal excretion of cortisol. No such changes have been reported for normal subjects. Neither the increased excretion nor the time shift was related to the mood response to TSD. The DST results were also unrelated to this response. Indications that the mood response to TSD may be mediated by dimensions of arousal are the significant relationships between this response and the responses of subjective stress and activation to TSD. The TSD-induced cortisol increase was not related to the subjective arousal response to TSD. The increased cortisol excretion itself could be predicted by the averaged baseline levels of subjective stress: the lower the stress levels before TSD, the larger the cortisol response to TSD.
在一组16名抑郁症患者中，研究了完全睡眠剥夺（TSD）的临床反应是否由唤醒维度介导。在TSD前3天、期间和之后2天评估激活、压力和情绪的自我报告。还测量了尿皮质醇排泄和对地塞米松抑制试验（DST）的反应。TSD增加了抑郁症患者的皮质醇排泄，并提前了皮质醇最大排泄时间。正常受试者未报告此类变化。排泄增加和时间变化均与对TSD的情绪反应无关。DST结果也与这种反应无关。表明对TSD的情绪反应可能由唤醒维度介导的迹象是这种反应与主观压力和对TSD的激活反应之间的显著关系。TSD诱导的皮质醇增加与对TSD的主观唤醒反应无关。皮质醇排泄增加本身可以通过主观压力的平均基线水平来预测：TSD前压力水平越低，则对TSD的皮质醇反应越大。
