通过情绪的昼夜变化预测对完全睡眠剥夺的抗抑郁反应。

Prediction of the antidepressant response to total sleep deprivation by diurnal variation of mood.

作者信息

Reinink E, Bouhuys N, Wirz-Justice A, van den Hoofdakker R

机构信息

Department of Biological Psychiatry, Psychiatric University Clinic, Groningen, The Netherlands.

出版信息

Psychiatry Res. 1990 May;32(2):113-24. doi: 10.1016/0165-1781(90)90077-i.

DOI:10.1016/0165-1781(90)90077-i

PMID:2367598

Abstract

The relationship between diurnal variation of mood and response to total sleep deprivation (TSD) was investigated in 131 depressed patients. This response was related to (1) the diurnal variation on the day before TSD as assessed by self-ratings of mood, and (2) the propensity to produce diurnal variations (the "diurnality") as assessed by the Hamilton Rating Scale for Depression. Three types of diurnality are distinguished: morning type (the propensity to feel better in the morning), evening type (the propensity to feel better in the evening), and a nondiurnal type. The results show that diurnality does predict the mood response to TSD. The direction of diurnality is decisive: patients who have the propensity to feel better in the evening benefit more from TSD than other patients.

摘要

对131名抑郁症患者的情绪日变化与完全睡眠剥夺（TSD）反应之间的关系进行了研究。这种反应与（1）TSD前一天通过情绪自评评估的日变化，以及（2）通过汉密尔顿抑郁量表评估的产生日变化的倾向（“日节律性”）有关。区分了三种日节律性类型：早晨型（早晨感觉更好的倾向）、晚上型（晚上感觉更好的倾向）和非日节律性类型。结果表明，日节律性确实可以预测对TSD的情绪反应。日节律性的方向起决定性作用：晚上有感觉更好倾向的患者比其他患者从TSD中获益更多。