Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Pharmacy School, Federal University of Rio Grande do Sul. Av. Ipiranga 2752. CEP 90610- 000. Porto Alegre, RS, Brazil.
Mini Rev Med Chem. 2013 Mar;13(3):318-34. doi: 10.2174/138955713804999775.
Coumarins and flavonoids are heterocyclic molecules that have been associated with beneficial effects on human health, such as reducing the risk of cancer, diabetes, cardiovascular and brain diseases. These effects are thought to be related to the radical scavenging effect, due to their antioxidant activities, along with other possible mechanisms, such as anti-inflammatory properties and interaction with several enzymes. Over the past two decades, there have been an increasing number of publications on coumarins and flavonoids, which demonstrate the importance of understanding the chemistry behind the antioxidant activities of both natural and synthesized compounds, considering the benefits from their dietary ingestion as well as pharmacological use. This work aims to review the antioxidant effects of coumarin and flavonoid molecules in humans and the structural aspects that contribute to these effects.
香豆素和黄酮类化合物是杂环分子，它们与人类健康的有益影响有关，如降低癌症、糖尿病、心血管和脑部疾病的风险。这些作用被认为与自由基清除作用有关，这是由于它们的抗氧化活性，以及其他可能的机制，如抗炎特性和与几种酶的相互作用。在过去的二十年中，关于香豆素和黄酮类化合物的出版物越来越多，这表明了解天然和合成化合物抗氧化活性背后的化学原理的重要性，既要考虑到它们作为饮食摄入的益处，也要考虑到它们在药理学上的应用。这项工作旨在综述香豆素和黄酮类化合物分子在人体中的抗氧化作用，以及对这些作用有贡献的结构方面。
