Tanner Amanda E, Roof Katherine A, Katz Barry P, Katschke Adrian, Fortenberry J Dennis, Zimet Gregory D
Department of Public Health Education, University of North Carolina Greensboro, Greensboro, NC 27401, USA.
Sex Health. 2012 Sep;9(4):299-303. doi: 10.1071/SH11063.
This study examined young women's actual timing of use of a microbicide surrogate gel (vaginal moisturiser (VM)) compared with assigned timing conditions.
Participants used a VM with coitus during 4-week cycles over a 3-year period in random timing sequences: 1h before coitus, 10 min before coitus and 10 min after coitus. Daily diaries collected information related to coital behaviours, VM use and timing, and participants' and partners' VM assessments. Descriptive and mixed-effects model analyses were conducted.
At least three VM timing conditions were completed by 109 women aged 18-22 years old. Of 17?772 diary days collected, coitus was reported on 2128 (1252 with VM use; 59%). Median times between VM application and coitus were: 60 min before coitus (mean=68.2; s.d.=76.9) for the 1-h pre-coital group, 13.5 min before coitus (mean=44.9; s.d.=117.1) for the 10-min pre-coital group and 5 min before coitus (mean=24.5; s.d.=205.1) for the 10-min post-coital group. Women reported that the VM was very easy to use (68%), it was somewhat messy (61%), they were very wet during sex (81%), sex was very good (80%) and their partners liked using the VM (38%).
Overall, the VM was rated positively. There was substantial deviation in application time across timing conditions, with significantly greater variability in the post-coital group. These findings contribute to understanding of how VMs are accepted and used, with implications for HIV prevention with microbicides requiring specific application timing.
本研究调查了年轻女性使用杀微生物剂替代凝胶（阴道保湿剂（VM））的实际时间，并与指定的时间条件进行比较。
在3年期间，参与者在4周的周期内按照随机时间顺序在性交时使用VM：性交前1小时、性交前10分钟和性交后10分钟。每日日记收集了与性交行为、VM使用和时间以及参与者和伴侣对VM的评估相关的信息。进行了描述性和混合效应模型分析。
109名18 - 22岁的女性完成了至少三种VM时间条件。在收集的17772个日记日中，报告性交的有2128天（其中1252天使用了VM；占59%）。VM应用与性交之间的中位时间分别为：性交前1小时组为性交前60分钟（平均值 = 68.2；标准差 = 76.9），性交前10分钟组为性交前13.5分钟（平均值 = 44.9；标准差 = 117.1），性交后10分钟组为性交前5分钟（平均值 = 24.5；标准差 = 205.1）。女性报告称VM非常易于使用（68%），有点 messy（61%），她们在性交时非常湿润（81%），性生活非常好（80%），并且她们的伴侣喜欢使用VM（38%）。
总体而言，VM的评价是积极的。不同时间条件下的应用时间存在显著偏差，性交后组的变异性明显更大。这些发现有助于理解VM的接受和使用情况，对需要特定应用时间的杀微生物剂预防HIV具有启示意义。
