Candace Best is assistant professor, Department of Psychology, Georgia Regents University, Augusta.
Perspect Sex Reprod Health. 2014 Mar;46(1):15-22. doi: 10.1363/46E0114. Epub 2013 Dec 10.
In time, microbicides may provide women with dual prevention against pregnancy and STDs. Although several microbicide dimensions have been evaluated, little is known about women's preferences for contraceptive microbicides and correlates of these preferences.
Acceptability of a hypothetical contraceptive microbicide cream or jelly was examined among a -clinic-based sample of 266 women in Indianapolis from 2004 (when participants were aged 14-22) to 2008. Group conjoint analyses and individual conjoint analyses were used to compare preferences with respect to four microbicide -dimensions: contraceptive ability, efficacy in relation to condoms, timing of use and texture. Pearson's product moment correlations were used to examine the relationship between preferences for a contraceptive microbicide and selected characteristics of the women.
Overall, the top-rated microbicide dimensions were efficacy in relation to that of condoms and contraceptive ability (importance scores, 40.0 and 35.4 out of 100.0, respectively). When all dimension levels were compared, contraceptive ability was the most strongly preferred (part-worth utility score, 8.9), and lower efficacy than that of -condoms was the least strongly preferred (-11.9). Preference for contraceptive microbicides was positively -associated with current contraceptive use, sexual agency, partner communication, commitment to avoiding pregnancy and -perceived partner agreement about avoiding pregnancy (coefficients, 0.07-0.18). It was negatively associated with current or past nonuse of contraceptives, seeking pregnancy and perceived partner agreement about seeking -pregnancy (-0.08 to -0.14).
Microbicides with dual prevention properties may be attractive to young women. Microbicide development and subsequent clinical trials should incorporate contraceptive microbicides.
随着时间的推移,杀微生物剂可能会为女性提供双重避孕和 STD 预防。尽管已经评估了几种杀微生物剂的维度,但对于女性对避孕杀微生物剂的偏好以及这些偏好的相关性知之甚少。
对印第安纳波利斯基于诊所的 266 名女性进行了假设避孕杀微生物剂乳膏或凝胶的可接受性调查,这些女性来自 2004 年(当时参与者年龄为 14-22 岁)至 2008 年。使用群组联合分析和个体联合分析来比较四个杀微生物剂维度的偏好:避孕能力、与避孕套的功效关系、使用时间和质地。Pearson 积矩相关用于检验对避孕杀微生物剂的偏好与女性特征之间的关系。
总体而言,评分最高的杀微生物剂维度是与避孕套的功效关系和避孕能力(重要性评分,分别为 40.0 和 35.4 分/100.0 分)。当比较所有维度水平时,避孕能力是最受青睐的(部分价值效用评分,8.9),而低于避孕套的功效是最不受青睐的(-11.9)。避孕杀微生物剂的偏好与当前避孕措施的使用、性自主、伴侣沟通、避免怀孕的承诺和感知到伴侣对避免怀孕的一致意见呈正相关(系数,0.07-0.18)。它与当前或过去不使用避孕药具、寻求怀孕和感知到伴侣对寻求怀孕的一致意见呈负相关(-0.08 至-0.14)。
具有双重预防特性的杀微生物剂可能对年轻女性具有吸引力。杀微生物剂的开发和随后的临床试验应纳入避孕杀微生物剂。