Minguijón E, González L, De las Heras M, Gómez N, García-Goti M, Juste R A, Moreno B
Departamento de Sanidad Animal, NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario, Derio, Vizcaya, Spain.
J Comp Pathol. 2013 Feb;148(2-3):139-47. doi: 10.1016/j.jcpa.2012.06.003. Epub 2012 Aug 9.
Seven sheep with a histopathological diagnosis of pulmonary adenocarcinoma with extrathoracic metastases were included in this retrospective study aiming to describe the pathological findings and to establish their relationship with Jaagsiekte sheep retrovirus (JSRV). In order of frequency, extrathoracic metastases were found in the liver, kidneys, skeletal muscle, digestive tract, spleen, skin and adrenal glands. Intrathoracic metastases involved the chest wall, regional lymph nodes, diaphragm and heart. Immunohistochemistry and polymerase chain reaction allowed detection of JSRV-related protein and nucleic acid, respectively, in the extrathoracic tumours of all cases. It is concluded that extrathoracic metastases constitute a pathological event of ovine pulmonary adenocarcinoma and confirm the malignant character of this virus-induced neoplasia.
本回顾性研究纳入了7只经组织病理学诊断为伴有胸外转移的肺腺癌的绵羊，旨在描述病理结果并确定其与绵羊肺腺瘤逆转录病毒（JSRV）的关系。按出现频率排序，胸外转移见于肝脏、肾脏、骨骼肌、消化道、脾脏、皮肤和肾上腺。胸内转移累及胸壁、区域淋巴结、膈肌和心脏。免疫组织化学和聚合酶链反应分别在所有病例的胸外肿瘤中检测到了JSRV相关蛋白和核酸。得出的结论是，胸外转移构成了绵羊肺腺癌的一个病理事件，并证实了这种病毒诱导的肿瘤形成的恶性特征。
