Suppr超能文献

高剂量皮下注射免疫球蛋白成功治疗常见可变免疫缺陷中的复发性脊髓炎。

Recurrent myelitis in common variable immunodeficiency successfully managed with high-dose subcutaneous immunoglobulin.

作者信息

Danieli Maria Giovanna, Pettinari Lucia, Marinangeli Lucia, Logullo Francesco

机构信息

Scienze Cliniche e Molecolari, Clinica Medica, Torrette di Ancona, Italy.

出版信息

BMJ Case Rep. 2012 Aug 8;2012:bcr0120125637. doi: 10.1136/bcr-01-2012-5637.

Abstract

Acute myelitis is an aetiologically heterogeneous inflammatory disorder of the spinal cord. We report on a 71-year-old woman with a recurrent cervical and thoracic myelitis who presented with a new relapse of the disease. Neuromyelitis optica was ruled out such as other possible causes of acute and/or recurrent myelopathy. Serum immunoglobulin levels and specific antibody responses were consistent with the diagnosis of common variable immunodeficiency (CVID). She was treated with high-dose methylprednisolone and intravenous immunoglobulin. As a remission-maintaining drug, we decided to treat her with subcutaneous immunoglobulin (CSL Behring) at 0.2 g/kg/week at doses higher than usually employed in replacement therapy in CVID. At 3-year follow-up, the response to treatment was good. No relapses occurred. Our case suggests the effectiveness and safety of subcutaneous immunoglobulin in maintaining remission and in sparing prednisone in a woman with recurrent myelitis associated with CVID.

摘要

急性脊髓炎是一种病因异质性的脊髓炎性疾病。我们报告了一名71岁复发性颈胸段脊髓炎女性患者,此次出现疾病新的复发。已排除视神经脊髓炎及其他急性和/或复发性脊髓病的可能病因。血清免疫球蛋白水平和特异性抗体反应符合常见可变免疫缺陷(CVID)的诊断。她接受了大剂量甲泼尼龙和静脉注射免疫球蛋白治疗。作为维持缓解药物,我们决定以高于CVID替代治疗通常使用剂量的0.2 g/kg/周皮下注射免疫球蛋白(CSL Behring)对她进行治疗。在3年随访中,治疗反应良好。未发生复发。我们的病例提示皮下注射免疫球蛋白在维持一名与CVID相关的复发性脊髓炎女性患者缓解及减少泼尼松用量方面的有效性和安全性。

相似文献

2
[A case of recurrent myelitis associated with anti-myelin oligodendrocyte glycoprotein antibody that developed only as localized short spinal cord lesions].
Rinsho Shinkeigaku. 2017 Nov 25;57(11):729-732. doi: 10.5692/clinicalneurol.cn-001014. Epub 2017 Oct 26.
4
Recurrent spinal cord attacks in a patient with a limited form of neuromyelitis optica.
Intern Med. 2011;50(5):509-13. doi: 10.2169/internalmedicine.50.4430. Epub 2011 Mar 1.
5
[Elderly onset case of neuromyelitis optica that developed at the age of 90].
Rinsho Shinkeigaku. 2018 Dec 21;58(12):761-763. doi: 10.5692/clinicalneurol.cn-001208. Epub 2018 Nov 29.
6
[A case of anti aquapolin-4 antibody positive myelitis with hyperhidrosis, following herpes zoster].
Rinsho Shinkeigaku. 2017 Jan 31;57(1):26-28. doi: 10.5692/clinicalneurol.cn-000820. Epub 2016 Dec 23.
8
Efficacy of intravenous cyclophosphamide therapy for neuromyelitis optica spectrum disorder.
Intern Med. 2013;52(9):969-72. doi: 10.2169/internalmedicine.52.7885. Epub 2012 Mar 1.
9
Longitudinally extensive transverse myelitis: a rare association with common variable immunodeficiency.
Pract Neurol. 2015 Feb;15(1):49-52. doi: 10.1136/practneurol-2014-000953. Epub 2014 Oct 21.
10
A case of neuromyelitis optica developing into myelitis 25 years after optic neuritis.
Jpn J Ophthalmol. 2010 Jul;54(4):372-3. doi: 10.1007/s10384-010-0818-9. Epub 2010 Aug 11.

引用本文的文献

2
The Central Nervous System Effects and Mimicry of Common Variable Immunodeficiency (CVID): A Case Report with Literature Review.
Case Rep Rheumatol. 2019 Sep 29;2019:7623643. doi: 10.1155/2019/7623643. eCollection 2019.
3
Neurologic Complications of Common Variable Immunodeficiency.
J Clin Immunol. 2016 Nov;36(8):793-800. doi: 10.1007/s10875-016-0336-8. Epub 2016 Oct 4.

本文引用的文献

2
Transverse myelitis.
Autoimmun Rev. 2012 Jan;11(3):231-48. doi: 10.1016/j.autrev.2011.05.018. Epub 2011 May 18.
5
Subcutaneous immunoglobulin in polymyositis and dermatomyositis: a novel application.
Autoimmun Rev. 2011 Jan;10(3):144-9. doi: 10.1016/j.autrev.2010.09.004. Epub 2010 Sep 19.
6
Evidence for the use of intravenous immunoglobulins--a review of the literature.
Clin Rev Allergy Immunol. 2010 Apr;38(2-3):201-69. doi: 10.1007/s12016-009-8155-9.
7
Acute transverse myelitis: a practical reappraisal.
Autoimmun Rev. 2009 Dec;9(2):128-31. doi: 10.1016/j.autrev.2009.04.005. Epub 2009 Apr 21.
8
Common variable immunodeficiency-associated myelitis: report of treatment with infliximab.
J Neurol. 2008 Nov;255(11):1821-4. doi: 10.1007/s00415-008-0898-3. Epub 2008 Jul 21.
9
What is the contents of the magic draft IVIg?
Autoimmun Rev. 2008 Jun;7(6):435-9. doi: 10.1016/j.autrev.2008.04.012. Epub 2008 May 2.
10
Severe steroid-resistant post-infectious encephalomyelitis: general features and effects of IVIg.
J Neurol. 2007 Nov;254(11):1518-23. doi: 10.1007/s00415-007-0561-4. Epub 2007 Nov 14.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验