Marquart K H
Calcif Tissue Int. 1979 Nov 6;28(3):259-62. doi: 10.1007/BF02441245.
The proximal tibial metaphysis of apparently healthy strain 101 mice, 3-4 weeks old, and (C3H X 101)F1 hybrids, 3-48 weeks old, was studied by electron microscopy. Budding, immature, and mature (C-type virus particles were found within trabecular bone tissue of 3 of 8 strain 101 and 4 of 12 (C3H X 101)F1 mice. The particles were most common in lacunae of aging osteocytes and were only occasionally associated with osteoblasts. Although the morphology of budding and immature particles appeared to be identical with that of typical C-type viruses, most of the mature forms of particles showed atypical structure and size. The electron-dense core was very large and not clearly defined, measuring approximately 70-130 nm in diameter. This diffuse core sometimes completely filled the space within the envelope of the particles. The diameters of the pleomorphic mature C-type particles ranged from approximately 90 to 150 nm. The possible association between the production of pleomorphic C-type virus particles by bone cells and spontaneous osteomagenesis in 101 and (C3H X 101)F1 mice is discussed.
运用电子显微镜对3至4周龄的健康101品系小鼠以及3至48周龄的（C3H×101）F1杂交小鼠的胫骨近端干骺端进行了研究。在8只101品系小鼠中的3只以及12只（C3H×101）F1小鼠中的4只的小梁骨组织内发现了出芽型、未成熟型和成熟型（C型病毒颗粒）。这些颗粒在衰老骨细胞的陷窝中最为常见，仅偶尔与成骨细胞相关。尽管出芽型和未成熟型颗粒的形态似乎与典型C型病毒的形态相同，但大多数成熟型颗粒呈现出非典型的结构和大小。电子致密核心非常大且界限不清，直径约为70至130纳米。这种弥散的核心有时会完全填满颗粒包膜内的空间。多形性成熟C型颗粒的直径范围约为90至150纳米。文中讨论了骨细胞产生多形性C型病毒颗粒与101品系和（C3H×101）F1小鼠自发性骨生成之间可能存在的关联。
