鼻内接种传染性牛鼻气管炎疫苗诱导的干扰素、抗体反应及保护作用
Interferon, antibody responses and protection induced by an intranasal infectious bovine rhinotracheitis vaccine.
作者信息
Savan M, Angulo A B, Derbyshire J B
出版信息
Can Vet J. 1979 Aug;20(8):207-10.
Abstract
The interferon and antibody response induced by an intranasal infectious bovine rhinotracheitis vaccine was followed in 22 calves over a nine month period and the ability of these vaccinated calves to withstand challenge with virulent infectious bovine rhinotracheitis virus was assessed. Interferon was detected two to three days post-vaccination and disappeared by the tenth day. Nasal and serum antibodies appeared by day 7 and persisted for nine months. The calves challenged three days postvaccination came down with disease typical of infectious bovine rhinotracheitis, whereas calves challenged three weeks, three months or nine months postvaccination resisted infection.
摘要
在22头小牛中跟踪观察了鼻内接种传染性牛鼻气管炎疫苗诱导的干扰素和抗体反应，为期9个月，并评估了这些接种疫苗的小牛抵抗强毒传染性牛鼻气管炎病毒攻击的能力。接种疫苗后2至3天可检测到干扰素，到第10天消失。鼻抗体和血清抗体在第7天出现，并持续9个月。接种疫苗后3天接受攻击的小牛患上了典型的传染性牛鼻气管炎疾病，而接种疫苗后3周、3个月或9个月接受攻击的小牛抵抗了感染。
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