在宿主介导试验中对结肠致癌物1,2 - 二甲基肼和氧化偶氮甲烷致突变性的抑制剂

Inhibitors for the mutagenicities of colon carcinogens, 1,2-dimethylhydrazine and azoxymethane, in the host-mediated assay.

作者信息

Moriya M, Ohta T, Watanabe K, Watanabe Y, Sugiyama F, Miyazawa T, Shirasu Y

出版信息

Cancer Lett. 1979 Oct;7(6):325-30. doi: 10.1016/s0304-3835(79)80061-0.

Abstract

Inhibitory effects of several chemicals on the mutagenicities of 1,2-dimethylhydrazine (DMH) and azoxymethane (AOM) for Salmonella typhimurium G46 in the host-mediated assay were investigated. They were carbon disulfide (CS2), tetraethylthiuram disulfide (disulfiram, DSF), sodium diethyldithiocarbamate (SDDC), ethylene-bis(dithiocarbamato) manganese (Maneb), pyrazole (PZ), aminoacetonitrile hydrogen sulfate (AAN), and sodium selenite (SE). All the compounds, except for SE, inhibited the mutagenicities of DMH and AOM.

摘要

研究了几种化学物质在宿主介导试验中对鼠伤寒沙门氏菌G46的1,2 - 二甲基肼（DMH）和偶氮甲烷（AOM）致突变性的抑制作用。这些化学物质包括二硫化碳（CS2）、四乙基秋兰姆二硫化物（双硫仑，DSF）、二乙基二硫代氨基甲酸钠（SDDC）、乙撑双二硫代氨基甲酸锰（代森锰）、吡唑（PZ）、氨基乙腈硫酸氢盐（AAN）和亚硒酸钠（SE）。除SE外，所有化合物均抑制了DMH和AOM的致突变性。