Wattenberg L W, Fiala E S
J Natl Cancer Inst. 1978 Jun;60(6):1515-7. doi: 10.1093/jnci/60.6.1515.
Disulfiram, diethyldithiocarbamate, and bis-(ethylxanthogen) inhibit symmetrical 1,2-dimethylhydrazine dihydrochloride (DMH)-induced neoplasia of the large bowel in female CF1 mice. These three compounds contain a carbon disulfide (CS2) moiety in their structure. In the present study, CS2 itself was found to inhibit DMH-induced neoplasia of the large bowel in female CF1 mice. Thus a relatively simple compound is now available for investigation of the mechanism of inhibition of DMH-induced neoplasia by a group of sulfur-containing inhibitors having common structural features.
双硫仑、二乙基二硫代氨基甲酸盐和双（乙基黄原酸酯）可抑制1,2 - 二甲基肼二盐酸盐（DMH）诱导的雌性CF1小鼠大肠肿瘤形成。这三种化合物的结构中均含有二硫化碳（CS2）部分。在本研究中，发现CS2本身可抑制DMH诱导的雌性CF1小鼠大肠肿瘤形成。因此，现在有一种相对简单的化合物可用于研究一组具有共同结构特征的含硫抑制剂抑制DMH诱导肿瘤形成的机制。
