Wattenberg L W, Lam L K, Fladmoe A V, Borchert P
Cancer. 1977 Nov;40(5 Suppl):2432-5. doi: 10.1002/1097-0142(197711)40:5+<2432::aid-cncr2820400907>3.0.co;2-8.
Disulfiram (tetraethylthiuram disulfide, Antabuse) and sodium diethyldithiocarbamate, when added to the diet, inhibit 1,2-dimethylhydrazine (DMH)-induced neoplasia of the large bowel in female CF1 mice. Ethylene bis(dithiocarbamato)manganese (Maneb) and bis(ethylxanthogen), two pesticides with structural similarities to disulfiram, produce comparable inhibition of DHM. In other work, disulfiram was found to inhibit the carcinogenic effect of azoxymethane (AOM) on the large bowel. Under comparable conditions the inhibition of AOM was considerably less than that obtained with DMH as the carcinogen. The data suggest that disulfiram inhibits DMH metabolism at more than one oxidative step.
双硫仑（二硫化四乙秋兰姆，戒酒硫）和二乙基二硫代氨基甲酸钠添加到饮食中时，可抑制1,2 - 二甲基肼（DMH）诱导的雌性CF1小鼠大肠肿瘤形成。代森锰锌（乙撑双二硫代氨基甲酸锰）和双（乙基黄原酸酯）这两种与双硫仑结构相似的农药，对DMH有类似的抑制作用。在其他研究中，发现双硫仑可抑制偶氮甲烷（AOM）对大肠的致癌作用。在可比条件下，对AOM的抑制作用远小于以DMH作为致癌物时的抑制作用。数据表明，双硫仑在多个氧化步骤抑制DMH代谢。
