Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Boston, Massachusetts, USA.
J Bacteriol. 2012 Dec;194(23):6372-81. doi: 10.1128/JB.00262-12. Epub 2012 Aug 10.
The ferric uptake regulator (Fur) protein has been shown to function as a repressor of transcription in a number of diverse microorganisms. However, recent studies have established that Fur can function at a global level as both an activator and a repressor of transcription through both direct and indirect mechanisms. Fur-mediated indirect activation occurs via the repression of additional repressor proteins, or small regulatory RNAs, thereby activating transcription of a previously silent gene. Fur mediates direct activation through binding of Fur to the promoter regions of genes. Whereas the repressive mechanism of Fur has been thoroughly investigated, emerging studies on direct and indirect Fur-mediated activation mechanisms have revealed novel global regulatory circuits.
铁摄取调节蛋白（Fur）已被证明在许多不同的微生物中作为转录的抑制剂发挥作用。然而，最近的研究已经确定 Fur 可以通过直接和间接机制在全局水平上作为转录的激活剂和抑制剂发挥作用。Fur 介导的间接激活是通过抑制其他抑制蛋白或小调控 RNA 来实现的，从而激活先前沉默基因的转录。Fur 通过与基因启动子区域结合来介导直接激活。虽然 Fur 的抑制机制已经得到了深入研究，但对直接和间接 Fur 介导的激活机制的新兴研究揭示了新的全局调控回路。
