Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Zagazig University, Egypt.
Clin Biochem. 2012 Dec;45(18):1591-5. doi: 10.1016/j.clinbiochem.2012.07.108. Epub 2012 Aug 3.
Exposure to certain environmental toxins may be associated with increased risk of developing diabetes mellitus. The aim of the present study was to investigate the relation between chronic exposure to malathion and insulin resistance among farmers.
The study included 98 non diabetic farmers who handle agricultural insecticides during their field work. The range of the exposure period for agricultural pesticides was 15-20 years. All farmers were males with mean age 39±12 years. Another 90 administrative employees at Zagazig University Hospitals, non diabetic males age matched were selected as controls. History taking including family history for diabetes, assessment of blood pressure, height, weight, waist circumference and body mass index was done for all participants. Blood samples were withdrawn for measurement of malathion concentration, fasting blood glucose level and fasting insulin level for calculation of homeostasis model assessment of insulin resistance (HOMA-IR).
24.5% had positive family history for diabetes. It was observed that there was a significant increase in the mean values of malathion blood concentration among studied farmers compared to corresponding controls. There was a positive correlation between malathion blood concentration, waist circumference and insulin resistance. It was also observed that the increase in the mean values of waist circumference and body mass index was accompanied by a significant increase in the mean values of malathion blood concentration.
The current results suggested that chronic exposure of non diabetic farmers to organophosphorus malathion pesticides may induce insulin resistance. This effect tended to strengthen as waist circumference increases.
接触某些环境毒素可能与糖尿病风险增加有关。本研究旨在调查马拉硫磷慢性暴露与农民胰岛素抵抗之间的关系。
本研究纳入了 98 名非糖尿病农民，他们在田间作业时接触农业杀虫剂。接触农业农药的暴露期范围为 15-20 年。所有农民均为男性，平均年龄 39±12 岁。另外，我们选择了 90 名年龄匹配的扎加齐格大学医院行政员工作为对照组，他们均为非糖尿病男性。对所有参与者进行了病史询问，包括糖尿病家族史、血压、身高、体重、腰围和体重指数评估。采集血样测量马拉硫磷浓度、空腹血糖水平和空腹胰岛素水平，以计算胰岛素抵抗的稳态模型评估（HOMA-IR）。
24.5%的参与者有糖尿病家族史。与相应对照组相比，研究农民的马拉硫磷血浓度平均值明显升高。马拉硫磷血浓度、腰围和胰岛素抵抗之间存在正相关。还观察到，腰围和体重指数平均值的增加伴随着马拉硫磷血浓度平均值的显著增加。
目前的结果表明，非糖尿病农民长期接触有机磷马拉硫磷农药可能会导致胰岛素抵抗。这种影响随着腰围的增加而增强。
