儿童时期接触青石棉的成年人的全因死亡率和癌症发病率。

All-cause mortality and cancer incidence among adults exposed to blue asbestos during childhood.

机构信息

Western Australian Institute for Medical Research, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia.

出版信息

Am J Ind Med. 2013 Feb;56(2):133-45. doi: 10.1002/ajim.22103. Epub 2012 Aug 9.

DOI:10.1002/ajim.22103

PMID:22886909

Abstract

BACKGROUND

There are few data on the long-term health outcomes of exposure to asbestos in childhood. This study investigated cancer and mortality of adults exposed to blue asbestos as children.

METHODS

Data linkage to relevant health registries was used to identify cancers and mortality in a cohort of adults (n = 2,460) that had lived in an asbestos mining town during their childhood (<15 years).

RESULTS

There were 217 (93 female) incident cancers and 218 (70 female) deaths among the cohort. Compared with the Western Australian population females had elevated mesothelioma, ovarian and brain cancers, and increased "all cause" and "all cancer" mortality. Males had elevated mesothelioma, leukemia, prostate, brain, and colorectal cancers, and excess mortality from "all causes," "all cancers," circulatory disease, diseases of the nervous system, and accidents.

CONCLUSION

Exposure to blue asbestos in childhood is associated with an increased risk of cancer and mortality in adults.

摘要

背景

关于儿童接触石棉的长期健康后果的数据很少。本研究调查了儿童时期暴露于蓝石棉的成年人的癌症和死亡率。

方法

通过与相关健康登记处的数据链接，确定了一个曾在石棉矿区度过童年时期（<15 岁）的成年人群体（n=2460）的癌症和死亡率。

结果

该队列中有 217 名（93 名女性）新发病例癌症和 218 名（70 名女性）死亡。与西澳大利亚州人口相比，女性的间皮瘤、卵巢癌和脑瘤发病率较高，“所有原因”和“所有癌症”死亡率也较高。男性的间皮瘤、白血病、前列腺癌、脑瘤和结直肠癌发病率较高，“所有原因”、“所有癌症”、循环系统疾病、神经系统疾病和事故的死亡率也较高。