• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

磷脂翻转酶

Phospholipid flippases.

作者信息

Devaux P F

机构信息

Institut de Biologie Physico-Chimique, Paris, France.

出版信息

FEBS Lett. 1988 Jul 4;234(1):8-12. doi: 10.1016/0014-5793(88)81291-2.

DOI:10.1016/0014-5793(88)81291-2
PMID:3292284
Abstract

Protein mediated phospholipid translocation through membranes has been observed in rat liver endoplasmic reticulum and in the plasma membrane of erythrocytes as well as in a few other cell membranes. Lipid translocation in plasma membranes is ATP dependent and selectively accumulates aminophospholipids on the inner monolayers.

摘要

在大鼠肝脏内质网、红细胞质膜以及其他一些细胞膜中，已观察到蛋白质介导的磷脂跨膜转运。质膜中的脂质转运依赖于ATP，并在内侧单层选择性积累氨基磷脂。

相似文献

1
Phospholipid flippases.磷脂翻转酶
FEBS Lett. 1988 Jul 4;234(1):8-12. doi: 10.1016/0014-5793(88)81291-2.
2
Control of the transmembrane phospholipid distribution in eukaryotic cells by aminophospholipid translocase.氨基磷脂转位酶对真核细胞跨膜磷脂分布的调控。
Biotechnol Appl Biochem. 1990 Oct;12(5):517-22.
3
Membrane-associated cytoskeleton and transbilayer phospholipid asymmetry.膜相关细胞骨架与跨膜磷脂不对称性
Indian J Biochem Biophys. 1990 Dec;27(6):365-7.
4
The elusive flippases.
Curr Biol. 2004 Nov 9;14(21):R912-3. doi: 10.1016/j.cub.2004.10.008.
5
Protein-mediated transbilayer movement of lipids in eukaryotes and prokaryotes: the relevance of ABC transporters.真核生物和原核生物中蛋白质介导的脂质跨膜运动：ABC转运蛋白的相关性
Int J Antimicrob Agents. 2003 Sep;22(3):177-87. doi: 10.1016/s0924-8579(03)00217-6.
6
Impaired Ca2+-induced tyrosine phosphorylation and defective lipid scrambling in erythrocytes from a patient with Scott syndrome: a study using an inhibitor for scramblase that mimics the defect in Scott syndrome.斯科特综合征患者红细胞中钙离子诱导的酪氨酸磷酸化受损及脂质翻转缺陷：一项使用模拟斯科特综合征缺陷的翻转酶抑制剂的研究
Blood. 1998 Mar 15;91(6):2133-8.
7
Inhibition and stimulation of phospholipid scrambling activity. Consequences for lipid asymmetry, echinocytosis, and microvesiculation of erythrocytes.磷脂翻转活性的抑制与刺激。对红细胞脂质不对称性、棘红细胞增多症和微囊泡形成的影响。
Biochemistry. 2001 Aug 7;40(31):9438-46. doi: 10.1021/bi0107492.
8
Involvement of ATP-dependent aminophospholipid translocation in maintaining phospholipid asymmetry in diamide-treated human erythrocytes.
Biochim Biophys Acta. 1989 May 19;981(1):151-60. doi: 10.1016/0005-2736(89)90093-x.
9
Aminophospholipid translocase and proteins involved in transmembrane phospholipid traffic.氨基磷脂转位酶及参与跨膜磷脂转运的蛋白质。
Biophys Chem. 1997 Oct;68(1-3):221-31. doi: 10.1016/s0301-4622(97)00048-3.
10
Functions of phospholipid flippases.磷脂翻转酶的功能。
J Biochem. 2011 Feb;149(2):131-43. doi: 10.1093/jb/mvq140. Epub 2010 Dec 5.

引用本文的文献

1
Bilayer Membranes with Frequent Flip-Flops Have Tensionless Leaflets.双层膜频繁翻转具有无张力的脂质双层。
Nano Lett. 2019 Aug 14;19(8):5011-5016. doi: 10.1021/acs.nanolett.9b01239. Epub 2019 Jul 5.
2
Beyond apoptosis: the mechanism and function of phosphatidylserine asymmetry in the membrane of activating mast cells.超越细胞凋亡：活化肥大细胞膜上磷脂酰丝氨酸不对称性的机制与功能
Bioarchitecture. 2014;4(4-5):127-37. doi: 10.1080/19490992.2014.995516.
3
Interaction of dystrophin fragments with model membranes.肌营养不良蛋白片段与模型膜的相互作用。
Biophys J. 1997 Jun;72(6):2599-604. doi: 10.1016/S0006-3495(97)78903-3.
4
Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes.凋亡T淋巴细胞上作为吞噬细胞识别信号的磷脂酰丝氨酸暴露机制。
J Exp Med. 1995 Nov 1;182(5):1597-601. doi: 10.1084/jem.182.5.1597.
5
Abnormalities in the erythrocyte membrane in acute lymphoid leukaemia.急性淋巴细胞白血病红细胞膜的异常
Biochem J. 1989 Mar 15;258(3):903-6. doi: 10.1042/bj2580903.
6
Loss of membrane phospholipid asymmetry during activation of blood platelets and sickled red cells; mechanisms and physiological significance.
Mol Cell Biochem. 1989;91(1-2):23-31. doi: 10.1007/BF00228075.
7
Nonmediated flip-flop of phospholipid analogues in the erythrocyte membrane as probed by palmitoylcarnitine: basic properties and influence of membrane modification.棕榈酰肉碱探测红细胞膜中磷脂类似物的非介导翻转：基本特性及膜修饰的影响
J Membr Biol. 1989 Oct;111(2):169-78. doi: 10.1007/BF01871780.
8
Lipid transport pathways in mammalian cells.
Experientia. 1990 Jun 15;46(6):569-79. doi: 10.1007/BF01939695.
9
Assembly of lipids into membranes. Introduction.
Experientia. 1990 Jun 15;46(6):551-2. doi: 10.1007/BF01939692.
10
Lateral diffusion of erythrocyte phospholipids in model membranes comparison between inner and outer leaflet components.红细胞磷脂在模型膜中的侧向扩散：内外小叶成分的比较
Eur Biophys J. 1990;18(1):33-41. doi: 10.1007/BF00185418.