Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials, Hohe Straße 6, 01069 Dresden, Germany.
Macromol Rapid Commun. 2012 Sep 14;33(17):1420-31. doi: 10.1002/marc.201200382. Epub 2012 Aug 7.
This review covers the application of polymeric materials in stem cell bioengineering. Main emphasis is directed towards current material design concepts that mimic distinct exogenous signals of the stem cell microenvironment. Progress within the field of stem cell-specific biomaterials will be discussed, focusing on pluripotent, hematopoietic, mesenchymal and neural stem cells. The future role of biomaterials will be outlined with possible applications for cell reprogramming and engineering cancer cell microenvironments.
这篇综述涵盖了聚合物材料在干细胞生物工程中的应用。主要重点是目前的材料设计概念，这些概念模拟了干细胞微环境的独特外源性信号。将讨论干细胞特异性生物材料领域的进展，重点是多能性、造血、间充质和神经干细胞。还将概述生物材料的未来作用，及其在细胞重编程和工程化癌细胞微环境中的可能应用。
