C-O 交叉偶联：活化的芳基和杂芳基卤化物与脂肪醇的偶联。
C-O cross-coupling of activated aryl and heteroaryl halides with aliphatic alcohols.
机构信息
Department of Process Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
出版信息
Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9071-4. doi: 10.1002/anie.201203460. Epub 2012 Aug 6.
PMID:22887962
Abstract
A robust and general catalyst system facilitates the alkoxylation of activated heteroaryl halides with primary, secondary, and select tertiary alcohols without the need for an excess of either coupling partner. This catalyst system displays broad functional-group tolerance and excellent regioselectivity, and is insensitive to the order of reagent addition.
摘要
一种稳健且通用的催化剂体系可促进活性杂芳基卤化物与伯醇、仲醇和选择的叔醇的烷氧基化反应，而无需过量的偶联试剂。该催化剂体系具有广泛的官能团耐受性和出色的区域选择性，并且对试剂添加顺序不敏感。
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