Davis C G
Howard Hughes Medical Institute, University of California, San Francisco 94143-0724.
New Biol. 1990 May;2(5):410-9.
Epidermal growth factor (EGF) is a short peptide with a distinctive motif of six cysteines. This motif is found in many different proteins of diverse functions. One approach to determining the functional utility of EGF repeats is to undertake a methodical analysis of each individual protein. While this approach has met with some success, it has been applied to only a small fraction of all the EGF repeat-bearing proteins. A second approach is to consider all these proteins as a whole but give particular attention to structural and functional similarities. This review attempts a broad, although not comprehensive, survey of the families of proteins containing EGF repeats, with particular emphasis on the relative distribution of calcium-binding and noncalcium-binding EGF repeats.
表皮生长因子（EGF）是一种含有六个半胱氨酸独特基序的短肽。这种基序存在于许多功能各异的不同蛋白质中。确定EGF重复序列功能效用的一种方法是对每个单独的蛋白质进行系统分析。虽然这种方法取得了一些成功，但它仅应用于所有含有EGF重复序列的蛋白质中的一小部分。第二种方法是将所有这些蛋白质作为一个整体来考虑，但特别关注结构和功能上的相似性。本综述尝试对含有EGF重复序列的蛋白质家族进行广泛（尽管不全面）的调查，特别强调钙结合型和非钙结合型EGF重复序列的相对分布。
