Zhu Jinjin, Wang Yang, Cao Yuanyuan, Shen Jilong, Yu Li
The Key Laboratory of Microbiology and Parasitology of Anhui Province, The Key Laboratory of Zoonoses of High Institutions in Anhui, Department of Microbiology and Parasitology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Front Microbiol. 2021 Jun 17;12:666506. doi: 10.3389/fmicb.2021.666506. eCollection 2021.
microneme is a specialized secretory organelle that discharges its contents at the apical tip of this apicomplexan parasite in a sequential and regulated manner. Increasing number of studies on microneme proteins (MICs) have shown them as a predominant and important role in host cell attachment, invasion, motility and pathogenesis. In this review, we summarize the research advances in one of the most important MICs complexes, TgMIC1/4/6, which will contribute to improve the understanding of the molecular mechanism of infection and provide a theoretical basis for the effective control against
微线体是一种特殊的分泌细胞器,它以有序且受调控的方式在这种顶复门寄生虫的顶端释放其内容物。对微线体蛋白(MICs)的研究越来越多,表明它们在宿主细胞附着、侵袭、运动和发病机制中发挥着主要且重要的作用。在这篇综述中,我们总结了最重要的MICs复合物之一TgMIC1/4/6的研究进展,这将有助于增进对感染分子机制的理解,并为有效防控提供理论依据。