Yilmaz Ercan, Celik Onder, Celik Nilufer, Celik Ebru, Turkcuoglu Ilgin, Simsek Yavuz, Minareci Yagmur, Boz Mehmet, Aydin Suleyman
Department of Obstetrics and Gynecology, School of Medicine, Inonu University Biochemistry, Malatya State Hospital, Malatya, Turkey.
J Obstet Gynaecol Res. 2013 Jan;39(1):139-45. doi: 10.1111/j.1447-0756.2012.01955.x. Epub 2012 Aug 13.
Evidence suggests that orexin regulates food consumption, glucose metabolism and insulin secretion. Orexin may have a role in the pathogenesis of type II diabetes mellitus, however its role in gestational diabetes mellitus is not known. We aimed to assess maternal serum and cord blood orexin-A (OXA) concentrations in pregnant women with gestational diabetes mellitus (GDM).
Thirty-five pregnant women with GDM and 35 gestational-age-matched healthy pregnant subjects participated in the study. Maternal serum and cord blood OXA levels were measured with enzyme immunoassay at the time of birth. The correlations between maternal serum and cord blood OXA levels, anthropometric and metabolic parameters were also assessed.
The mean maternal and cord serum OXA (1.16±0.37 and 1.35±0.20ng/mL, respectively) in the GDM group were significantly different from those of the controls (1.58±0.59 and 1.25±0.21ng/mL, respectively). The mean maternal fasting-glucose-to-OXA ratio was significantly higher in the GDM group. In the GDM group, the mean maternal serum OXA levels were similar in the insulin (n=24) and diet (n=11) treated cases, respectively (1.13±0.36ng/mL and 1.21±0.41ng/mL). Maternal serum OXA levels positively correlated with fetal serum OXA and maternal glucose levels. OXA concentrations in maternal serum were negatively correlated with the fasting glucose, fasting insulin and homeostasis model assessment insulin resistance index.
Maternal serum OXA levels decrease, and fetal serum OXA levels increase in women with GDM.
有证据表明，食欲素调节食物摄入、葡萄糖代谢和胰岛素分泌。食欲素可能在2型糖尿病发病机制中起作用，然而其在妊娠期糖尿病中的作用尚不清楚。我们旨在评估妊娠期糖尿病（GDM）孕妇的母血和脐血食欲素A（OXA）浓度。
35例GDM孕妇和35例孕周匹配的健康孕妇参与了本研究。出生时采用酶免疫法测定母血和脐血OXA水平。还评估了母血和脐血OXA水平与人体测量和代谢参数之间的相关性。
GDM组孕妇和脐血血清OXA的平均值（分别为1.16±0.37和1.35±0.20ng/mL）与对照组（分别为1.58±0.59和1.25±0.21ng/mL）有显著差异。GDM组孕妇空腹血糖与OXA的平均比值显著更高。在GDM组中，接受胰岛素治疗（n=24）和饮食治疗（n=11）的孕妇血清OXA平均水平相似（分别为1.13±0.36ng/mL和1.21±0.41ng/mL）。母血OXA水平与胎儿血清OXA和孕妇血糖水平呈正相关。母血OXA浓度与空腹血糖、空腹胰岛素和稳态模型评估胰岛素抵抗指数呈负相关。
GDM孕妇母血OXA水平降低，胎儿血清OXA水平升高。
