Department of Obstetrics and Gynecology, Cerrahpasa Medical FacultyIstanbul University, Istanbul, Turkey -
Minerva Med. 2013 Oct;104(5):527-35.
The aim of this paper was to investigate maternal and cord blood apelin, resistin and visfatin concentrations in pregnant women with and without gestational diabetes mellitus (GDM).
This case-control study was conducted on 24 women with GDM and 21 women without GDM. Maternal plasma and cord blood apelin, resistin and visfatin levels were measured with ELISA.
The cord blood apelin levels were significantly lower in women with GDM than control subjects (111.23±31.53 vs.. 257.48±133.97 pg/mL, P=0.002). However, the decrease of maternal apelin levels in GDM group was not statistically significant (140.76±48.38 vs. 163.53±91.12 pg/mL, P=0.602). Women with GDM had lower maternal and cord blood visfatin concentrations and higher resistin concentrations than control group. Maternal resistin concentrations were significantly correlated with HOMA-IR (r=0.745, P=0.005). The apelin and visfatin levels did not correlate with HbA1c, BMI, HOMA-IR, glucose and birth weight.
GDM is associated with lower cord blood apelin levels than control subjects. GDM appears to influence fetoplacental apelin metabolism. Apelin may not be directly involved in the regulation of maternal insulin sensitivity. Our results indicate that there is an increase in resistin concentrations and a decrease in visfatin concentrations in maternal serum and cord blood serum with GDM.
本研究旨在探讨妊娠期糖尿病（GDM）孕妇与非 GDM 孕妇的母血和脐血中脂联素、抵抗素和内脂素浓度。
该病例对照研究纳入了 24 例 GDM 孕妇和 21 例非 GDM 孕妇。采用 ELISA 法检测母血和脐血中脂联素、抵抗素和内脂素的水平。
GDM 组孕妇脐血中脂联素水平明显低于对照组（111.23±31.53 比 257.48±133.97 pg/mL，P=0.002）。然而，GDM 组母血中脂联素水平的降低并无统计学意义（140.76±48.38 比 163.53±91.12 pg/mL，P=0.602）。与对照组相比，GDM 组孕妇的母血和脐血中内脂素浓度较低，抵抗素浓度较高。母血抵抗素浓度与 HOMA-IR 呈显著正相关（r=0.745，P=0.005）。脂联素和内脂素水平与 HbA1c、BMI、HOMA-IR、血糖和出生体重均无相关性。
与对照组相比，GDM 孕妇的脐血脂联素水平较低。GDM 似乎影响胎-胎盘脂联素代谢。脂联素可能不直接参与调节母体胰岛素敏感性。我们的研究结果表明，GDM 孕妇的母血清和脐血清中抵抗素浓度升高，内脂素浓度降低。
