Department of Preventive Medicine, Preventive Cardiology, Oslo University Hospital, Ullevål, Oslo, Norway.
Metab Syndr Relat Disord. 2012 Dec;10(6):437-42. doi: 10.1089/met.2012.0012. Epub 2012 Aug 13.
Low-grade inflammation is linked to metabolic syndrome and obesity. We studied the effects of weight loss and dietary composition on serum concentrations of biomarkers of inflammation and adipokines.
Men and women (n=181) aged 30-65 years with a body mass index (BMI) of 28-40 kg/m(2) (28-35 kg/m(2) for women) and one or more components of metabolic syndrome were randomized to follow one of two hypocaloric diets, a low-fat or low-glycemic-load diet for 3 months. Blood samples were taken pre- and postintervention. Serum concentrations of interleukin-6 (IL-6), tumor necrosis factorα (TNF-α), plasminogen activator inhibitor-1 (PAI-1), monocyte chemoattractant protein-1 (MCP-1), and adipokines (leptin, resistin, and adiponectin) were analyzed using multiplexed microsphere immunoassays.
Weight loss was not different in the low-fat (4.4%±3.8%) and low-glycemic-load (4.9%±3.2%) groups. Concentrations of IL-6, TNF-α, PAI-1, and leptin were significantly reduced in both dietary groups with no between-group differences, whereas MCP-1 and adiponectin concentrations did not change. Subjects with full metabolic syndrome (three or more components; n=109) experienced greater weight loss than subjects (n=72) with one to two components and greater reduction in leptin [7.08 (95% confidence interval 5.19, 8.97) vs. 3.46 (0.91, 6.00) ng/mL; p=0.02] and a tendency to greater reduction in TNF-α (1.00 [0.60, 1.44] vs 0.40 [0.02, 0.78] pg/mL; p=0.05).
Hypocaloric diets improved inflammatory biomarkers and adipokines independently of dietary composition. The response tended to be greater in subjects with three or more components of metabolic syndrome than their counterparts with one to two components.
低度炎症与代谢综合征和肥胖有关。我们研究了减肥和饮食成分对炎症生物标志物和脂肪因子血清浓度的影响。
年龄在 30-65 岁、体重指数（BMI）为 28-40kg/m2（女性为 28-35kg/m2）且存在一种或多种代谢综合征成分的男性和女性参与者（n=181）被随机分为两组，分别遵循两种低热量饮食：低脂或低血糖负荷饮食，为期 3 个月。在干预前后采集血样。采用多重微球免疫分析方法检测血清中白细胞介素-6（IL-6）、肿瘤坏死因子α（TNF-α）、纤溶酶原激活物抑制剂-1（PAI-1）、单核细胞趋化蛋白-1（MCP-1）和脂肪因子（瘦素、抵抗素和脂联素）的浓度。
低脂（4.4%±3.8%）和低血糖负荷（4.9%±3.2%）两组的体重减轻程度无差异。两种饮食组的 IL-6、TNF-α、PAI-1 和瘦素浓度均显著降低，两组间无差异，而 MCP-1 和脂联素浓度无变化。存在三种或更多种代谢综合征成分的受试者（n=109）比仅存在一到两种成分的受试者（n=72）体重减轻更多，瘦素降低幅度更大[7.08（95%置信区间 5.19，8.97）vs. 3.46（0.91，6.00）ng/mL；p=0.02]，TNF-α也有降低趋势[1.00（0.60，1.44）vs 0.40（0.02，0.78）pg/mL；p=0.05]。
低热量饮食可独立于饮食成分改善炎症生物标志物和脂肪因子。在存在三种或更多种代谢综合征成分的受试者中，这种反应的幅度大于仅存在一到两种成分的受试者。
