晚期胃癌患者的神经导向因子 1 浓度及其与治疗的关系。

Netrin-1 concentrations in patients with advanced gastric cancer and its relation with treatment.

机构信息

Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey.

出版信息

Biomarkers. 2012 Nov;17(7):663-7. doi: 10.3109/1354750X.2012.709882. Epub 2012 Aug 13.

DOI:10.3109/1354750X.2012.709882

PMID:22889408

Abstract

CONTEXT

Netrin-1 is found to be elevated and usable as a diagnostic biomarker in many human cancers.

OBJECTIVES

We evaluated serum Netrin-1 concentrations in patients with advanced gastric cancer compared with those in a healthy group.

MATERIAL AND METHODS

Thirty patients with advanced gastric cancer and thirty healthy people were included in the study. Serum netrin-1 concentrations were measured by quantitative ELISA method in both groups.

RESULTS

The mean serum Netrin-1 concentrations were found to be significantly higher in patients with gastric cancer than in healthy controls. The mean serum Netrin-1 concentrations were found to be significantly higher in patients with gastric cancer before the beginning of chemotherapy when compared after the completion of third cycle.

DISCUSSION AND CONCLUSION

Our results indicated that netrin-1 concentrations elevated in advanced gastric cancer compared to a healthy control group and netrin-1 concentrations decreased with chemotherapy.

摘要