Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands.
Osteoarthritis Cartilage. 2012 Nov;20(11):1278-85. doi: 10.1016/j.joca.2012.08.001. Epub 2012 Aug 10.
To investigate cross-sectional and predictive associations of plasma adipokines with biochemical markers of systemic joint metabolism and radiographic signs of early-stage knee osteoarthritis (OA).
The adipokines pLeptin, pAdiponectin, and pResistin, the cartilage markers C-terminal telopeptide of type II collagen (uCTX-II), N-terminal propeptide of type IIA procollagen (sPIIANP), chondroitin sulfate 846 (sCS846), and cartilage oligomeric matrix protein (sCOMP), and the synovial markers hyaluronic acid (sHA) and N-terminal propeptide of type III procollagen (sPIIINP) were assessed by enzyme-linked immunosorbent assay or radioactive immunoassay in baseline samples of Cohort Hip and Cohort Knee (CHECK), a cohort of 1002 subjects with early-stage symptomatic knee and/or hip OA. Knee radiographs were obtained at baseline and after 2 and 5 years and scored according to Kellgren & Lawrence.
pLeptin showed positive associations with uCTX-II, sCOMP, sPIIANP, sHA, and sPIIINP, and with presence and progression of radiographic knee OA. Associations expectedly disappeared after adjustment for body mass index. pResistin showed positive associations with sPIIINP and present and incident radiographic knee OA that were largely independent of BMI. pAdiponectin showed positive associations with uCTX-II and sCOMP. Furthermore, pAdiponectin did not show associations with radiographic knee OA on itself, but associations of pResistin with present radiographic knee OA were stronger in higher pAdiponectin tertiles (P = 0.024 for interaction between pAdiponectin and pResistin). Although statistically significant, all associations were weak.
Adipokines may have aggravating, although may be minor, structural effects in early-stage knee OA.
探讨血浆脂肪因子与全身关节代谢生化标志物及早期膝关节骨关节炎（OA）放射学征象的横断面及预测相关性。
通过酶联免疫吸附试验或放射性免疫分析法检测队列髋关节和队列膝关节（CHECK）中基线样本中的脂肪因子瘦素（pLeptin）、脂联素（pAdiponectin）和抵抗素（pResistin），以及软骨标志物 II 型胶原 C 端肽（uCTX-II）、IIA 型前胶原 N 端肽（sPIIANP）、硫酸软骨素 846（sCS846）和软骨寡聚基质蛋白（sCOMP）、滑膜标志物透明质酸（sHA）和 III 型前胶原 N 端肽（sPIIINP）。在基线时和 2 年及 5 年后获取膝关节 X 线片，并根据 Kellgren & Lawrence 进行评分。
瘦素与 uCTX-II、sCOMP、sPIIANP、sHA 和 sPIIINP 呈正相关，与膝关节 OA 的放射学表现和进展呈正相关。在调整体重指数后，这些相关性消失。抵抗素与 sPIIINP 及现有的和新发的膝关节 OA 呈正相关，且与 BMI 相关性不大。脂联素与 uCTX-II 呈正相关。此外，脂联素本身与膝关节 OA 的放射学表现无关，但抵抗素与现有的膝关节 OA 的相关性在脂联素较高三分位时更强（p 与脂联素和抵抗素之间的交互作用=0.024）。虽然具有统计学意义，但所有相关性均较弱。
脂肪因子可能对早期膝关节 OA 具有加重作用，尽管可能作用较小。
