Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, Instituto de Ciências da Saúde, Rua Augusto Corrêa, N°01, 66075-900 Belém, Pará, Brazil.
J Ethnopharmacol. 2012 Sep 28;143(2):604-10. doi: 10.1016/j.jep.2012.07.020. Epub 2012 Aug 7.
Petiveria alliacea (Phytolaccaceae) is a perennial shrub indigenous to the Amazon Rainforest and tropical areas of Central and South America, the Caribbean, and sub-Saharan Africa. In folk medicine, Petiveria alliacea has a broad range of therapeutic properties; however, it is also associated with toxic effects.
The present study evaluated the putative effects of Petiveria alliacea on the central nervous system, including locomotor activity, anxiety, depression-like behavior, and memory, and oxidative stress.
Two-month-old male and female Wistar rats (n=7-10 rats/group) were administered with 900 mg/kg of hydroalcoholic extracts of Petiveria alliacea L. The behavioral assays included open-field, forced swimming, and elevated T-maze tests. The oxidative stress levels were measured in rat blood samples after behavioral assays and methemoglobin levels were measured in vitro.
Consistent with previous reports, Petiveria alliacea increased locomotor activity. It also exerted previously unreported anxiolytic and antidepressant effects in behavioral tests. In the oxidative stress assays, the Petiveria alliacea extract decreased Trolox equivalent antioxidant capacity levels and increased methemoglobin levels, which was related to the toxic effects.
The Petiveria alliacea extract exerted motor stimulatory and anxiolytic effects in the OF test, antidepressant effects in the FS test, and elicited memory improvement in ETM. Furthermore, the Petiveria alliacea extract also exerted pro-oxidant effects in vitro and in vivo, inhibiting the antioxidant status and increasing MetHb levels in human plasma, respectively.
鱼腥草（商陆科）是一种原产于亚马逊雨林和中美洲、南美洲、加勒比海和撒哈拉以南非洲热带地区的多年生灌木。在民间医学中，鱼腥草具有广泛的治疗特性；然而，它也与毒性作用有关。
本研究评估了鱼腥草对中枢神经系统的潜在影响，包括运动活动、焦虑、抑郁样行为和记忆以及氧化应激。
两个月大的雄性和雌性 Wistar 大鼠（n=7-10 只/组）给予 900mg/kg 的鱼腥草水醇提取物。行为测定包括旷场、强迫游泳和高架 T 迷宫试验。在行为测定后测量大鼠血液样本中的氧化应激水平，并在体外测量高铁血红蛋白水平。
与先前的报告一致，鱼腥草增加了运动活动。它还在行为测试中表现出以前未报道的抗焦虑和抗抑郁作用。在氧化应激测定中，鱼腥草提取物降低了 Trolox 等效抗氧化能力水平并增加了高铁血红蛋白水平，这与毒性作用有关。
鱼腥草提取物在 OF 试验中表现出运动刺激和抗焦虑作用，在 FS 试验中表现出抗抑郁作用，在 ETM 中表现出记忆改善作用。此外，鱼腥草提取物还在体外和体内表现出促氧化作用，分别抑制了人体血浆中的抗氧化状态并增加了 MetHb 水平。
