使用血池造影剂的高分辨率CT血管成像。
High-resolution CT vascular imaging using blood pool contrast agents.
作者信息
Annapragada Ananth V, Hoffman Eric, Divekar Abhay, Karathanasis Efstathios, Ghaghada Ketan B
机构信息
Singleton Department of Pediatric Radiology, Texas Children’s Hospital, Houston, TX, USA.
出版信息
Methodist Debakey Cardiovasc J. 2012 Jan;8(1):18-22. doi: 10.14797/mdcj-8-1-18.
Abstract
While the evolution of computed tomography imaging in the last 2 decades has been driven almost exclusively by improvements in the instrumentation and processing algorithms, there have been comparatively modest advances in contrast agent technology.A notable change in the last decade has been the development of blood pool contrast agents based on nanoparticle technology.While not yet ready for clinical use, the stable and uniform opacification provided by these agents in normal vasculature and controlled extravasation in compromised vasculature enables novel techniques for imaging and diagnosis of pathologies. This manuscript presents preclinical examples demonstrating cardiovascular pathologies and tumor characterization by high-resolution computed tomography imaging.
摘要
在过去20年里，计算机断层扫描成像技术的发展几乎完全是由仪器设备和处理算法的改进推动的，而造影剂技术的进展相对较小。过去十年的一个显著变化是基于纳米颗粒技术的血池造影剂的开发。虽然这些造影剂尚未准备好用于临床，但它们在正常血管系统中提供的稳定且均匀的显影以及在受损血管系统中的可控外渗，使得成像和病理诊断的新技术成为可能。本文展示了通过高分辨率计算机断层扫描成像对心血管疾病和肿瘤特征进行表征的临床前实例。
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本文引用的文献
1
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Acad Radiol. 2011 Jan;18(1):20-30. doi: 10.1016/j.acra.2010.09.003.
2
CT coronary angiography: 256-slice and 320-detector row scanners.CT 冠状动脉成像：256 层和 320 层探测器扫描仪。
Curr Cardiol Rep. 2010 Jan;12(1):68-75. doi: 10.1007/s11886-009-0075-z.
3
Incidence of contrast-induced nephropathy after contrast-enhanced computed tomography in the outpatient setting.门诊患者行增强计算机断层扫描后对比剂肾病的发生率。
Clin J Am Soc Nephrol. 2010 Jan;5(1):4-9. doi: 10.2215/CJN.05200709. Epub 2009 Dec 3.
4
Multi-slice computed tomography with N1177 identifies ruptured atherosclerotic plaques in rabbits.多排螺旋计算机断层扫描 N1177 可识别兔破裂的粥样硬化斑块。
Basic Res Cardiol. 2010 Jan;105(1):51-9. doi: 10.1007/s00395-009-0052-0. Epub 2009 Aug 20.
5
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PLoS One. 2009 Jun 9;4(6):e5843. doi: 10.1371/journal.pone.0005843.
6
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Ann Intern Med. 2009 Feb 3;150(3):170-7. doi: 10.7326/0003-4819-150-3-200902030-00006.
7
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8
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9
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Radiographics. 2008 Nov-Dec;28(7):2009-22. doi: 10.1148/rg.287085004.
10
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