La Francesca Saverio
Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, USA.
Methodist Debakey Cardiovasc J. 2012 Jan;8(1):28-35. doi: 10.14797/mdcj-8-1-28.
The use of stem cell therapy for the treatment of cardiovascular diseases has generated significant interest in recent years. Limitations to the clinical application of this therapy center on issues of stem cell delivery, engraftment, and fate. Nanotechnology-based cell labeling and imaging techniques facilitate stem cell tracking and engraftment studies. Nanotechnology also brings exciting new opportunities to translational stem cell research as it enables the controlled engineering of nanoparticles and nanomaterials that can properly relate to the physical scale of cell-cell and cell-niche interactions. This review summarizes the most relevant potential applications of nanoscale technologies to the field of stem cell therapy for the treatment of cardiovascular diseases.
近年来，干细胞疗法用于治疗心血管疾病已引起了广泛关注。该疗法临床应用的局限性集中在干细胞递送、植入和命运等问题上。基于纳米技术的细胞标记和成像技术有助于干细胞追踪和植入研究。纳米技术还为转化干细胞研究带来了令人兴奋的新机遇，因为它能够对纳米颗粒和纳米材料进行可控工程设计，使其与细胞间和细胞与微环境相互作用的物理尺度相匹配。本文综述了纳米技术在心血管疾病干细胞治疗领域最相关的潜在应用。
