Department of Breast Surgery, Southwest Hospital, Army Medical University, Chongqing 400038,China.
Department of Hepatobiliary Surgery, Provincial People\'s Hospital, Xian, Shanxi, 710068,China.
Curr Stem Cell Res Ther. 2022;17(3):195-206. doi: 10.2174/1574888X16666210719110436.
Stem cell therapy is widely regarded as a promising strategy in regenerative medicine, yet the therapeutic effects of stem cells in vivo are limited by many factors when applied without additional factors, such as poor cell engraftment, uncontrolled differentiation, and unclear cell fates and niches. The emergence of nanotechnology has provided several solutions for these problems. Nanomaterial-based cell labeling and tracking have been extensively investigated in recent decades, and many innovative and multifunctional nanomaterials have been used to reveal the fate of stem cells, allowing more efficient, sensitive, and accurate imaging/tracking strategies for stem cells to be achieved. Nanomaterials enhance stem cell therapy by incorporating or integrating with stem cells and, as scaffolds or substrates, nanomaterials with antioxidant properties that can be used as graft coatings show great promise for clinical transformation. However, current reviews on the subject tend to focus on the various effects of nanomaterials on stem cells and are less concerned with their application to stem cell therapy. Accordingly, we herein present a review of progress in the application of nanomaterials in stem cell therapy over the last three years, which we hope will be of benefit to a comprehensive understanding of nanomaterial-mediated stem cell therapy from lab to pre-clinical practice.
干细胞治疗被广泛认为是再生医学中一种有前途的策略，但在没有额外因素的情况下应用时，干细胞在体内的治疗效果受到许多因素的限制，例如细胞植入不良、不受控制的分化以及细胞命运和微环境不明确。纳米技术的出现为这些问题提供了几种解决方案。基于纳米材料的细胞标记和示踪在最近几十年得到了广泛的研究，许多创新的多功能纳米材料被用于揭示干细胞的命运，使干细胞的成像/跟踪策略更加高效、灵敏和准确。纳米材料通过与干细胞结合或整合，并作为支架或基底，具有抗氧化特性的纳米材料可作为移植物涂层，具有很大的临床转化潜力。然而，目前关于该主题的综述往往侧重于纳米材料对干细胞的各种影响，而较少关注其在干细胞治疗中的应用。因此，我们在此综述了过去三年中纳米材料在干细胞治疗中的应用进展，希望这将有助于全面了解从实验室到临床前实践中纳米材料介导的干细胞治疗。
