纳米技术在复杂组织工程中的策略。
Nanotechnological strategies for engineering complex tissues.
机构信息
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
Nat Nanotechnol. 2011 Jan;6(1):13-22. doi: 10.1038/nnano.2010.246. Epub 2010 Dec 12.
Abstract
Tissue engineering aims at developing functional substitutes for damaged tissues and organs. Before transplantation, cells are generally seeded on biomaterial scaffolds that recapitulate the extracellular matrix and provide cells with information that is important for tissue development. Here we review the nanocomposite nature of the extracellular matrix, describe the design considerations for different tissues and discuss the impact of nanostructures on the properties of scaffolds and their uses in monitoring the behaviour of engineered tissues. We also examine the different nanodevices used to trigger certain processes for tissue development, and offer our view on the principal challenges and prospects of applying nanotechnology in tissue engineering.
摘要
组织工程旨在开发用于受损组织和器官的功能性替代品。在移植之前，细胞通常被接种在生物材料支架上，这些支架可以再现细胞外基质，并为细胞提供对组织发育很重要的信息。在这里，我们回顾了细胞外基质的纳米复合材料性质，描述了不同组织的设计考虑因素，并讨论了纳米结构对支架性能的影响及其在监测工程组织行为中的应用。我们还研究了用于触发某些组织发育过程的不同纳米器件，并对应用纳米技术在组织工程中的主要挑战和前景提出了看法。
相似文献
1
Nanotechnological strategies for engineering complex tissues.纳米技术在复杂组织工程中的策略。
Nat Nanotechnol. 2011 Jan;6(1):13-22. doi: 10.1038/nnano.2010.246. Epub 2010 Dec 12.
2
Biomimetic materials for tissue engineering.用于组织工程的仿生材料。
Adv Drug Deliv Rev. 2008 Jan 14;60(2):184-98. doi: 10.1016/j.addr.2007.08.041. Epub 2007 Nov 28.
3
Tissue engineering on the nanoscale: lessons from the heart.纳米尺度的组织工程：心脏的启示。
Curr Opin Biotechnol. 2013 Aug;24(4):664-71. doi: 10.1016/j.copbio.2012.10.016. Epub 2012 Nov 8.
4
Novel opportunities and challenges offered by nanobiomaterials in tissue engineering.纳米生物材料在组织工程中带来的新机遇与挑战。
Int J Nanomedicine. 2008;3(4):415-24.
5
Biomaterial scaffolds for tissue engineering.用于组织工程的生物材料支架
Front Biosci (Elite Ed). 2013 Jan 1;5(1):341-60. doi: 10.2741/e620.
6
Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review.近期去细胞化细胞外基质生物墨水 3D 打印技术的研究进展：最新综述。
Int J Mol Sci. 2019 Sep 18;20(18):4628. doi: 10.3390/ijms20184628.
7
The Emerging Role of Decellularized Plant-Based Scaffolds as a New Biomaterial.脱细胞植物支架作为新型生物材料的新兴作用。
Int J Mol Sci. 2021 Nov 16;22(22):12347. doi: 10.3390/ijms222212347.
8
Recent development and biomedical applications of decellularized extracellular matrix biomaterials.脱细胞细胞外基质生物材料的最新发展及其在生物医学中的应用。
Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109942. doi: 10.1016/j.msec.2019.109942. Epub 2019 Jul 3.
9
Decellularized tendon-based heparinized nanocomposite scaffolds for prospective regenerative applications: Chemical, physical, thermal, mechanical and in vitro biological evaluations.脱细胞肌腱基肝素化纳米复合支架用于有前景的再生应用：化学、物理、热学、力学和体外生物学评价。
J Mech Behav Biomed Mater. 2022 Oct;134:105387. doi: 10.1016/j.jmbbm.2022.105387. Epub 2022 Jul 21.
10
Hybrid and Composite Scaffolds Based on Extracellular Matrices for Cartilage Tissue Engineering.基于细胞外基质的杂交和复合支架在软骨组织工程中的应用。
Tissue Eng Part B Rev. 2019 Jun;25(3):202-224. doi: 10.1089/ten.TEB.2018.0245.
引用本文的文献
1
Pre-Loading of Cells via Vapor Sublimation and the Deposition Polymerization Process with a 3D Porous Scaffold for Cell Cultures.通过蒸汽升华和沉积聚合过程对细胞进行预加载，并结合用于细胞培养的三维多孔支架。
ACS Biomater Sci Eng. 2025 Aug 11;11(8):4941-4953. doi: 10.1021/acsbiomaterials.5c00439. Epub 2025 Jul 10.
2
The Intersection of Stem Cells and Nanomaterials: Implications for Tissue Engineering and Regenerative Medicine.干细胞与纳米材料的交叉领域：对组织工程和再生医学的影响
Stem Cell Rev Rep. 2025 May 27. doi: 10.1007/s12015-025-10897-6.
3
Chitin nanofibers: recent advances in preparation and applications in biomedical and beyond.几丁质纳米纤维：制备及其在生物医学及其他领域应用的最新进展
RSC Adv. 2025 May 19;15(19):14655-14690. doi: 10.1039/d4ra06937d. eCollection 2025 May 6.
4
Bioelectric and physicochemical foundations of bioelectronics in tissue regeneration.组织再生中生物电子学的生物电和物理化学基础。
Biomaterials. 2025 Nov;322:123385. doi: 10.1016/j.biomaterials.2025.123385. Epub 2025 May 2.
5
"Live" Nanomaterials Process Biomimetic Recognition and Assembly In Vivo.“活性”纳米材料在体内进行仿生识别与组装。
Small Sci. 2023 Oct 10;3(11):2300032. doi: 10.1002/smsc.202300032. eCollection 2023 Nov.
6
Direct nanopatterning of complex 3D surfaces and self-aligned superlattices via molecular-beam holographic lithography.通过分子束全息光刻技术对复杂三维表面进行直接纳米图案化及自对准超晶格
Nat Commun. 2025 Apr 11;16(1):3436. doi: 10.1038/s41467-025-58651-3.
7
Silk Fibroin Surface Engineering Using Phase Separation Approaches for Enhanced Cell Adhesion and Proliferation.利用相分离方法进行丝素蛋白表面工程以增强细胞黏附和增殖
ACS Appl Mater Interfaces. 2025 Mar 5;17(9):13702-13712. doi: 10.1021/acsami.5c00874. Epub 2025 Feb 19.
8
Synthesis and characterization of magnetic nanoparticle-incorporated nanohydroxyapatite and calcium and phosphate ion clusters for biomimetic remineralization of enamel and dentin.用于牙釉质和牙本质仿生再矿化的磁性纳米颗粒复合纳米羟基磷灰石及钙磷离子簇的合成与表征
J Conserv Dent Endod. 2024 Dec;27(12):1294-1299. doi: 10.4103/JCDE.JCDE_707_24. Epub 2024 Dec 10.
9
Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management.用于心律失常管理的新型电活性治疗平台。
Adv Sci (Weinh). 2025 Jun;12(24):e2500061. doi: 10.1002/advs.202500061. Epub 2025 Feb 14.
10
Current Advances and Future Directions of Pluripotent Stem Cells-Derived Engineered Heart Tissue for Treatment of Cardiovascular Diseases.用于治疗心血管疾病的多能干细胞衍生工程心脏组织的当前进展与未来方向
Cells. 2024 Dec 18;13(24):2098. doi: 10.3390/cells13242098.
本文引用的文献
1
Design and Implementation of Functional Nanoelectronic Interfaces With Biomolecules, Cells, and Tissue Using Nanowire Device Arrays.使用纳米线器件阵列设计并实现与生物分子、细胞及组织的功能性纳米电子接口。
IEEE Trans Nanotechnol. 2010 May;9(3):269-280. doi: 10.1109/TNANO.2009.2031807.
2
Chemically Functionalized Carbon Nanotubes as Substrates for Neuronal Growth.化学功能化碳纳米管作为神经元生长的基质
Nano Lett. 2004 Mar;4(3):507-511. doi: 10.1021/nl035193d.
3
Three-dimensional, flexible nanoscale field-effect transistors as localized bioprobes.三维、柔性纳米尺度场效应晶体管作为局域生物探针。
Science. 2010 Aug 13;329(5993):830-4. doi: 10.1126/science.1192033.
4
Microstructure and cytocompatibility of electrospun nanocomposites based on poly(epsilon-caprolactone) and carbon nanostructures.基于聚己内酯和碳纳米结构的电纺纳米复合材料的微观结构与细胞相容性
Int J Artif Organs. 2010 May;33(5):271-82.
5
Tissue-engineered lungs for in vivo implantation.用于体内植入的组织工程肺。
Science. 2010 Jul 30;329(5991):538-41. doi: 10.1126/science.1189345. Epub 2010 Jun 24.
6
Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix.利用去细胞化肝脏基质开发可移植再细胞化肝脏移植物进行器官再工程。
Nat Med. 2010 Jul;16(7):814-20. doi: 10.1038/nm.2170. Epub 2010 Jun 13.
7
Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires.通过精确操纵的纳米线实现细胞内细胞因子的亚细胞分辨率传递。
Nat Nanotechnol. 2010 Jul;5(7):545-51. doi: 10.1038/nnano.2010.104. Epub 2010 Jun 13.
8
The effect of immobilized RGD peptide in macroporous alginate scaffolds on TGFbeta1-induced chondrogenesis of human mesenchymal stem cells.固定化 RGD 肽对 TGFβ1 诱导的人骨髓间充质干细胞软骨形成的影响。
Biomaterials. 2010 Sep;31(26):6746-55. doi: 10.1016/j.biomaterials.2010.05.025. Epub 2010 Jun 12.
9
Biodegradable, photocrosslinked alginate hydrogels with independently tailorable physical properties and cell adhesivity.具有独立可调节物理性能和细胞黏附性的可生物降解、光交联海藻酸盐水凝胶。
Tissue Eng Part A. 2010 Sep;16(9):2915-25. doi: 10.1089/ten.TEA.2010.0096.
10
Toxicology of engineered nanomaterials: focus on biocompatibility, biodistribution and biodegradation.工程纳米材料的毒理学：关注生物相容性、生物分布和生物降解
Biochim Biophys Acta. 2011 Mar;1810(3):361-73. doi: 10.1016/j.bbagen.2010.04.007. Epub 2010 May 8.
Zotero 插件