Calzone Kathleen A, Jenkins Jean
National Institutes of Health, National Cancer Institute, Center for Cancer Research, Genetics Branch, Bethesda, MD, USA.
Annu Rev Nurs Res. 2011;29:151-72. doi: 10.1891/0739-6686.29.151.
Discovery of the genetics/genomics underpinnings of health, risk for disease, sickness, and treatment response have the prospects of improving recognition and management of at risk individuals; improving screening, prognostics, and therapeutic decision-making; expanding targeted therapies; and improving the accuracy of medication dosing and selection based on drug metabolism genetic variation. Thus, genetics/genomics science, information, and technologies influence the entire health care continuum and are fundamental to the nursing profession. Translating the benefits of genetics and genomics into health care requires that nurses are knowledgeable about and able to integrate this information and technology into their practice. This chapter explores the development of essential nursing competences in genetics and genomics and outcome indicators. Included is an overview of projects aimed at measuring and/or supporting adoption and integration of such competencies. Included as well is an update reviewing current evidence of the state of genomics nursing education in the United States and recommendations for next steps.
发现健康、疾病风险、患病情况及治疗反应的遗传学/基因组学基础，有望改善对高危个体的识别与管理；改进筛查、预后评估及治疗决策；拓展靶向治疗；并基于药物代谢基因变异提高药物剂量选择和用药准确性。因此，遗传学/基因组学科学、信息及技术影响着整个医疗保健连续过程，对护理专业至关重要。将遗传学和基因组学的益处转化为医疗保健服务，要求护士了解并能够将这些信息和技术融入其实践中。本章探讨了遗传学和基因组学方面基本护理能力及成果指标的发展情况。其中包括旨在衡量和/或支持此类能力的采用与整合的项目概述。此外，还更新了对美国基因组学护理教育现状的现有证据审查及后续步骤建议。
