Department of Chemistry, School of Science and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an 710049, China.
Org Lett. 2012 Sep 7;14(17):4358-61. doi: 10.1021/ol301801r. Epub 2012 Aug 14.
An efficient catalytic decarboxylative acylation of unactivated sp(2) (alkenyl) C-H bonds has been developed. Various substituted α-oxocarboxylic acids with different electronic properties react under mild conditions to afford a diverse range of β-acyl enamide products in good yields. The reaction is proposed to proceed via a cyclic vinylpalladium intermediate, facilitating the decarboxylative dehydrogenative process with enamide coupling partners.
一种高效的未活化 sp(2)（烯基）C-H 键催化脱羧酰化反应已被开发出来。各种取代的具有不同电子性质的α-氧代羧酸在温和条件下反应，以良好的收率得到各种不同的β-酰基烯酰胺产物。该反应被认为是通过一个环状的 vinylpalladium 中间体进行的，该中间体有利于与烯酰胺偶联伙伴进行脱羧脱氢过程。
