铜（I）催化的 2-取代色氨酸与碘𬭩盐的级联去芳构化反应。

Copper(I)-catalyzed cascade dearomatization of 2-substituted tryptophols with iodonium [corrected] salts.

机构信息

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.

出版信息

Org Lett. 2012 Sep 7;14(17):4525-7. doi: 10.1021/ol301939w. Epub 2012 Aug 14.

DOI:10.1021/ol301939w

PMID:22891935

Abstract

Copper(I)-catalyzed dearomative arylation and vinylation of 2-substituted tryptophols were realized with a subsequent cyclization reaction. The cascade dearomatization sequence provided versatile furoindoline derivatives with two quaternary carbon centers in good to excellent yields.

摘要

铜（I）催化的 2-取代色氨酸的去芳构化芳基化和乙烯基化反应，并伴随着随后的环化反应。级联去芳构化序列以良好至优秀的收率提供了具有两个季碳原子的多功能呋喃并吲哚啉衍生物。