用于透皮给药的聚氨酯微结构的合成及初步体内评价
Synthesis and preliminary in vivo evaluations of polyurethane microstructures for transdermal drug delivery.
作者信息
Borcan Florin, Soica Codruta M, Ganta Srinivas, Amiji Mansoor M, Dehelean Cristina A, Munteanu Melania F
机构信息
Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy Timisoara, 2nd E, Murgu Sq,, Timisoara, 300041, Romania.
出版信息
Chem Cent J. 2012 Aug 14;6(1):87. doi: 10.1186/1752-153X-6-87.
BACKGROUND
Polymers have been considered as important materials in fabrication of microstructures for various medical purposes including drug delivery. This study evaluates polyurethane as material for hollow microstructures preparation.
RESULTS
Polyurethane microstructures were obtained by interfacial polyaddition combined with spontaneous emulsification and present slightly acid pH values. Scanning electron microscopy revealed the existence of irregular shapes and agglomerated microstructures. The material is heat resistant up to 280°C. Good results were recorded on murine skin tests in case of polyurethane microstructures based on isophorone diisocyanate. Mesenchymal stem cells viability presents good results for the same sample after 48 hours based on the Alamar Blue test.
CONCLUSIONS
The research revealed the reduced noxiousness of this type of microstructures and consequently the possibility of their use for therapeutic purposes.
背景
聚合物被认为是用于制造各种医疗用途（包括药物递送）微结构的重要材料。本研究评估聚氨酯作为制备中空微结构的材料。
结果
通过界面聚加成结合自发乳化获得聚氨酯微结构，其pH值呈微酸性。扫描电子显微镜显示存在不规则形状和团聚的微结构。该材料耐热至280°C。基于异佛尔酮二异氰酸酯的聚氨酯微结构在小鼠皮肤试验中取得了良好结果。基于阿拉玛蓝试验，相同样品在48小时后间充质干细胞活力呈现良好结果。
结论
该研究揭示了这类微结构的低毒性，因此有可能将其用于治疗目的。
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