Department of Functional Sciences-Pathophysiology, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timișoara, Romania.
Center for Translational Research and Systems Medicine, Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timișoara, Romania.
Oxid Med Cell Longev. 2021 Mar 2;2021:3165159. doi: 10.1155/2021/3165159. eCollection 2021.
Phytocompounds and medicinal herbs were used in traditional ancient medicine and are nowadays increasingly screened in both experimental and clinical settings due to their beneficial effects in several major pathologies. Similar to the drug industry, phytotherapy is interested in using nanobased delivery systems to view the identification and characterization of the cellular and molecular therapeutic targets of plant components. Eugenol, the major phenolic constituent of clove essential oil, is a particularly versatile phytochemical with a vast range of therapeutic properties, among which the anti-inflammatory, antioxidant, and anticarcinogenic effects have been systematically addressed. In the past decade, with the emerging understanding of the role of mitochondria as critical organelles in the pathophysiology of noncommunicable diseases, research regarding the role of phytochemicals as modulators of bioenergetics and metabolism is on a rise. Here, we present a brief overview of the major pharmacological properties of eugenol, with special emphasis on its applications in dental medicine, and provide preliminary data regarding its effects, alone, and included in polyurethane nanostructures, on mitochondrial bioenergetics, and glycolysis in human HaCaT keratinocytes.
植物化合物和草药在传统的古代医学中被使用，现在由于它们在几种主要病理中的有益作用，在实验和临床环境中越来越受到筛选。与制药行业一样，植物疗法也有兴趣使用基于纳米的递药系统来观察植物成分的细胞和分子治疗靶点的鉴定和表征。丁香精油中的主要酚类成分丁香酚是一种特别多功能的植物化学物质，具有广泛的治疗特性，其中抗炎、抗氧化和抗癌作用已得到系统研究。在过去的十年中，随着人们对线粒体作为非传染性疾病病理生理学中关键细胞器的作用的认识不断提高，关于植物化学物质作为生物能量学和代谢调节剂的作用的研究正在兴起。在这里，我们简要概述了丁香酚的主要药理学特性，特别强调了它在牙科医学中的应用，并提供了关于其单独使用以及包含在聚氨酯纳米结构中的作用的初步数据，这些作用对人 HaCaT 角质形成细胞的线粒体生物能量学和糖酵解有影响。
