Center for Melanoma Research and Treatment, Department of Surgery, California Pacific Medical Center and Sutter Pacific Medical Foundation, California Pacific Medical Center Research Institute, 2340 Clay Street, 2nd Floor, San Francisco, CA 94115, USA.
Clin Exp Metastasis. 2012 Oct;29(7):861-4. doi: 10.1007/s10585-012-9522-0. Epub 2012 Aug 15.
Cancer progression from the primary site to the regional lymph nodes and beyond to the distant sites through the lymphovascular system is genetically determined. In general, sentinel lymph node in the regional lymph nodes is the gateway for metastasis. Biomarkers are becoming increasingly important to define different phases of metastasis. With further understanding of the molecular mechanisms of metastasis, more targets are available for selective therapeutic intervention so that effective therapy can be delivered against cancer in a more personalized approach.
癌症从原发部位向区域淋巴结、淋巴管系统以及远处转移部位的进展是由遗传因素决定的。一般来说，区域淋巴结中的前哨淋巴结是转移的门户。生物标志物在定义转移的不同阶段方面变得越来越重要。随着对转移分子机制的进一步了解，更多的靶点可用于选择性的治疗干预，以便以更个体化的方式针对癌症提供有效的治疗。
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