Chen Ying, Xiang Honggang, Zhang Yingfan, Wang Jiejun, Yu Guanzhen
Department of Medical Oncology, Changzheng Hospital, Hetian Road 64, Shanghai, 200070, China.
Clin Exp Metastasis. 2015 Jun;32(5):417-28. doi: 10.1007/s10585-015-9712-7. Epub 2015 Apr 14.
Microarray studies revealed down-regulation of PCDH9 mRNA level in lymph node metastasis of gastric cancer compared with the primary tumors. The expression of PCDH9 protein and its clinicopathological relevance were assessed on tissue microarrays of 1072 cases of gastric cancer. Its prognostic value was further evaluated on a small cohort of 175 gastric cancers. PCDH9 was down-regulated during the development and progression of gastric cancer. The overall rates of PCDH9 expression in normal, primary tumor, nodal and hepatic metastatic tissues were 100 % (1072/1072), 48.0 % (515/1072), 20.1 % (34/169), and 5.6 % (1/18), respectively. Positive staining of PCDH9 protein was significantly reversely correlated with tumor size, tumor differentiation, tumor invasion, lymph node metastasis, and disease progression. The Cox proportional hazards model revealed that the PCDH9 was an independent prognostic factor for gastric cancer. Therefore, decreased expression of PCDH9 is frequent in human gastric cancer metastasis and PCDH9 expression is an independent prognostic factor, suggesting that PCDH9 could be a promising biomarker of this malignancy.
基因芯片研究显示，与原发性肿瘤相比，PCDH9 mRNA水平在胃癌淋巴结转移中下调。在1072例胃癌组织芯片上评估了PCDH9蛋白的表达及其临床病理相关性。在一个由175例胃癌组成的小队列中进一步评估了其预后价值。在胃癌的发生和发展过程中，PCDH9表达下调。PCDH9在正常组织、原发性肿瘤、淋巴结和肝转移组织中的总体表达率分别为100%（1072/1072）、48.0%（515/1072）、20.1%（34/169）和5.6%（1/18）。PCDH9蛋白的阳性染色与肿瘤大小、肿瘤分化、肿瘤侵袭、淋巴结转移和疾病进展显著负相关。Cox比例风险模型显示，PCDH9是胃癌的独立预后因素。因此，PCDH9表达降低在人类胃癌转移中很常见，且PCDH9表达是一个独立的预后因素，这表明PCDH9可能是这种恶性肿瘤的一个有前景的生物标志物。
