University of Michigan, USA.
Autism. 2013 Nov;17(6):645-54. doi: 10.1177/1362361312453776. Epub 2012 Aug 14.
While there is no cure for autism spectrum disorder, psychopharmacologic agents are often used with behavioral and educational approaches to treat its comorbid symptoms of hyperactivity, irritability, and aggression. Studies suggest that at least 50% of persons with autism spectrum disorder receive psychotropic medications during their life span. This selective review examines recent studies about the use of psychotropic medications in persons with autism spectrum disorder. The aim was to focus on randomized controlled trials conducted from 1990 to 2010 on this topic. A comprehensive literature search was performed using PubMed and Cochrane databases. Out of 105 studies identified for the review, only 24 were randomized controlled trials. Thus, despite the common use of these medications in autism spectrum disorder, more controlled studies are needed to determine their long-term efficacy and safety.
虽然自闭症谱系障碍无法治愈，但通常会采用精神药理学药物与行为和教育方法相结合，来治疗其共病的多动、易怒和攻击性行为等症状。研究表明，至少有 50%的自闭症谱系障碍患者在其一生中会接受精神药物治疗。本选择性综述考察了关于自闭症谱系障碍患者使用精神药物的最新研究。其目的是集中关注 1990 年至 2010 年期间就该主题开展的随机对照试验。通过使用 PubMed 和 Cochrane 数据库进行了全面的文献检索。在为综述确定的 105 项研究中，仅有 24 项为随机对照试验。因此，尽管这些药物在自闭症谱系障碍中被广泛使用，但仍需要更多的对照研究来确定它们的长期疗效和安全性。
