动态不稳定性——原核生物和真核生物 DNA 分离与细胞分裂的共同特征。
Dynamic instability--a common denominator in prokaryotic and eukaryotic DNA segregation and cell division.
机构信息
Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
出版信息
Cell Mol Biol Lett. 2012 Dec;17(4):542-8. doi: 10.2478/s11658-012-0026-3. Epub 2012 Aug 15.
Abstract
Dynamic instability is an essential phenomenon in eukaryotic nuclear division and prokaryotic plasmid R1 segregation. Although the molecular machines used in both systems differ greatly in composition, strong similarities and requisite nuances in dynamics and segregation mechanisms are observed. This brief examination of the current literature provides a functional comparison between prokaryotic and eukaryotic dynamically unstable filaments, specifically ParM and microtubules. Additionally, this mini-review should support the notion that any dynamically unstable filament could serve as the molecular machine driving DNA segregation, but these machines possess auxiliary features to adapt to temporal and spatial disparities in either system.
摘要
动态不稳定性是真核核分裂和原核质粒 R1 分离的一个基本现象。尽管这两个系统中使用的分子机器在组成上有很大的不同，但在动力学和分离机制方面观察到了很强的相似性和必要的细微差别。本文简要回顾了目前的文献，对原核和真核动态不稳定丝，特别是 ParM 和微管之间的功能进行了比较。此外，本综述还支持了这样一种观点，即任何动态不稳定的纤维都可以作为驱动 DNA 分离的分子机器，但这些机器具有辅助特征，可以适应两个系统中时间和空间的差异。
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