Kim Jung Han, Saxton Arnold M
Department of Pharmacology, Physiology and Toxicology, Marshall University School of Medicine, Huntington, WV, USA.
Methods Mol Biol. 2012;933:75-87. doi: 10.1007/978-1-62703-068-7_6.
The TALLYHO/Jng (TH) mouse is an inbred polygenic model for type 2 diabetes (T2D) with moderate obesity. Both male and female TH mice are characterized by increased body and fat pad weights, hyperleptinemia, hyperinsulinemia, and hyperlipidemia. Glucose intolerance and hyperglycemia are exhibited only in males. Reduced 2-deoxy-glucose uptake occurs in adipose tissue and skeletal muscle of male TH mice. While both sexes of TH mice exhibit enlarged pancreatic islets, only males have degranulation and abnormal architecture in islets. Endothelial dysfunction and considerably decreased bone density are also observed in male TH mice. The blood pressure of male TH mice is normal. Genetic outcross experiments with non-diabetic strains revealed multiple susceptibility loci (quantitative trait loci) for obesity, hypertriglyceridemia, hypercholesterolemia, and hyperglycemia. In conclusion, TH mice encompass many aspects of polygenic human diabetes and are a very useful model for T2D.
TALLYHO/Jng（TH）小鼠是一种患有中度肥胖症的2型糖尿病（T2D）近交多基因模型。雄性和雌性TH小鼠均具有体重和脂肪垫重量增加、高瘦素血症、高胰岛素血症和高脂血症的特征。葡萄糖不耐受和高血糖仅在雄性小鼠中出现。雄性TH小鼠的脂肪组织和骨骼肌中2-脱氧葡萄糖摄取减少。虽然TH小鼠的雌雄两性均表现出胰岛增大，但只有雄性小鼠的胰岛有脱颗粒和异常结构。在雄性TH小鼠中还观察到内皮功能障碍和骨密度显著降低。雄性TH小鼠的血压正常。与非糖尿病品系的遗传杂交实验揭示了肥胖、高甘油三酯血症、高胆固醇血症和高血糖的多个易感基因座（数量性状基因座）。总之，TH小鼠涵盖了多基因人类糖尿病的许多方面，是T2D的一个非常有用的模型。
