Department of Chemistry, Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, USA.
Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9348-51. doi: 10.1002/anie.201204093. Epub 2012 Aug 15.
Methodology for the synthesis of alkaloid-pyrones using a novel pyrone annulation of β–carbolines and indoles with 3-siloxy-4-pyrones is reported. The approach has enabled semisynthesis of the unprecedented alkaloid-pyrone pleiomaltinine from the plant-derived indole-alkaloid pleiocarpamine.
本文报道了一种新型吡喃环合β-咔啉和吲哚与 3-硅氧基-4-吡喃酮的方法，用于合成生物碱-吡喃酮。该方法实现了从植物衍生的吲哚生物碱pleiocarpamine 中半合成前所未有的生物碱-吡喃酮 pleiomaltinine。
