生物碱-吡喃酮环化反应的发展：pleiomaltinine 的合成。
Development of an alkaloid-pyrone annulation: synthesis of pleiomaltinine.
机构信息
Department of Chemistry, Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, MA 02215, USA.
出版信息
Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9348-51. doi: 10.1002/anie.201204093. Epub 2012 Aug 15.
Abstract
Methodology for the synthesis of alkaloid-pyrones using a novel pyrone annulation of β–carbolines and indoles with 3-siloxy-4-pyrones is reported. The approach has enabled semisynthesis of the unprecedented alkaloid-pyrone pleiomaltinine from the plant-derived indole-alkaloid pleiocarpamine.
摘要
本文报道了一种新型吡喃环合β-咔啉和吲哚与 3-硅氧基-4-吡喃酮的方法，用于合成生物碱-吡喃酮。该方法实现了从植物衍生的吲哚生物碱pleiocarpamine 中半合成前所未有的生物碱-吡喃酮 pleiomaltinine。
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