活性亚砜物种介导吲哚衍生物 2α-位的功能化。
Active thionium species mediated functionalization at the 2α-position of indole derivatives.
机构信息
Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
出版信息
Chem Commun (Camb). 2011 Jun 21;47(23):6728-30. doi: 10.1039/c1cc11645b. Epub 2011 May 10.
PMID:21556439
Abstract
A combination of dimethyl sulfoxide (DMSO) and trifluoroacetic anhydride (TFAA) mediates functionalization at the 2α-position of indole derivatives. Carbon and heteroatom nucleophiles were directly introduced via a one-pot procedure in excellent yields.
摘要
二甲基亚砜（DMSO）和三氟乙酸酐（TFAA）的组合介导吲哚衍生物在 2α-位的功能化。通过一锅法以优异的收率直接引入碳和亲核试剂。
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